在沙特阿拉伯西部地区接受上皮性卵巢癌治疗的女性的生存和预后因素。
Survival and prognostic factors in women treated for epithelial ovarian cancer in western region of Saudi Arabia.
机构信息
From the Gynecology Oncology Unit, Obstetrics and Gynecology Department (Sait K, Sait H, Anfinan), form the Faculty of Medicine (Sait K, Sait H, Sait M), King Abdulaziz University; and from the Stem cell Unit Oncology Unit, Department of Medical Laboratory Technology (Alam, Haque), King Fahd Medical Research Center and Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
出版信息
Saudi Med J. 2022 Feb;43(2):146-155. doi: 10.15537/smj.2022.43.2.20210626.
OBJECTIVES
To assess survival and prognostic factors among women with epithelial ovarian cancer in Western Saudi Arabia.
METHODS
A retrospective cohort study was carried out between October 2000 and May 2018, reviewing clinical and pathology data of all women who underwent staging or debulking surgery for epithelial ovarian cancer. Analysis of disease-free survival (DFS), overall survivals (OS) and the associated factors used Kaplan-Meier method in addition to cox multivariate regression.
RESULTS
A total of 144 patients were included (median age=49.5 years), with a median follow-up time was 3.4 years. Majority (59.7%) of the patients were diagnosed at an advanced stage (III or IV). The mean (95% CI) DFS was 82.3 (67.8-96.8) months, OS was 96.2 (81.3-111.2) months, and the 5-year survival rate was estimated as 38.9%. Univariate analysis showed that older age, clear cell or papillary carcinoma subtypes, serous type, advanced International Federation of Gynecology and Obstetrics (FIGO) stage and the presence of residual disease were associated with poorer DFS and OS (log rank <0.05). Cox regression showed FIGO stage and residual disease >1cm as the strongest prognostic factors independently associated with DFS and OS.
CONCLUSION
Improving early diagnosis and achieving optimal cytoreduction are the most critical challenges to achieve significant positive impact on survival of women with epithelial ovarian cancer.
目的
评估沙特阿拉伯西部上皮性卵巢癌患者的生存情况和预后因素。
方法
这是一项回顾性队列研究，于 2000 年 10 月至 2018 年 5 月进行，对所有接受上皮性卵巢癌分期或肿瘤细胞减灭术的女性的临床和病理数据进行了回顾性分析。采用 Kaplan-Meier 法分析无病生存（DFS）、总生存（OS）和相关因素，并进行 cox 多因素回归分析。
结果
共纳入 144 例患者（中位年龄 49.5 岁），中位随访时间为 3.4 年。大多数（59.7%）患者在晚期（III 或 IV 期）诊断。DFS 的平均（95%CI）为 82.3（67.8-96.8）个月，OS 为 96.2（81.3-111.2）个月，5 年生存率估计为 38.9%。单因素分析显示，年龄较大、透明细胞或乳头状癌亚型、浆液型、国际妇产科联合会（FIGO）分期较晚、存在残留疾病与较差的 DFS 和 OS 相关（对数秩检验<0.05）。Cox 回归显示，FIGO 分期和残留疾病>1cm 是与 DFS 和 OS 独立相关的最强预后因素。
结论
改善早期诊断和实现最佳肿瘤细胞减灭术是对上皮性卵巢癌患者生存产生重大积极影响的最关键挑战。
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