Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan.
Department of Gastroenterology, South Miyagi Medical Center, Japan.
Intern Med. 2022 Aug 15;61(16):2441-2448. doi: 10.2169/internalmedicine.8253-21. Epub 2022 Feb 1.
A 69-year-old woman with multiple neuroendocrine neoplasms (NENs) was referred to our hospital. Although she had extreme hypergastrinemia (11,675 pg/mL), no findings that indicated types I to III gastric NENs were found. Although gastric corpus atrophy was suspected on conventional white-light imaging, findings on magnifying endoscopy with narrow-band imaging indicated no severe atrophy. A biopsy from the background fundic gland mucosa revealed no atrophic changes, parietal cells with vacuolated cytoplasm and negative findings for HK-ATPase. Thus, this case was diagnosed as multiple NENs with parietal cell dysfunction. Neither progression nor metastasis has been confirmed during two-year follow-up.
一位 69 岁的女性患有多种神经内分泌肿瘤（NENs），被转至我院。尽管她的胃泌素水平极高（11675pg/mL），但并未发现 I 型至 III 型胃 NEN 的相关表现。常规白光成像怀疑胃体萎缩，但窄带成像放大内镜检查并未发现严重的萎缩。对胃底腺黏膜的活检显示无萎缩性改变，壁细胞胞浆空泡化，HK-ATPase 检测为阴性。因此，该病例被诊断为伴有壁细胞功能障碍的多发性 NEN。在两年的随访期间，未发现疾病进展或转移。
