Laboratory of Clinical Pathology (Yang, Jung, Seo, Hwang, Yongbaek Kim); BK21 FOUR Program for Future Veterinary Medicine Leading Education and Research Center (Yang, Jung, Seo); Department of Veterinary Pathology (Go, Dae-Yong Kim); Research Institute for Veterinary Science (Dae-Yong Kim, Yongbaek Kim), College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
Can Vet J. 2022 Feb;63(2):139-142.
A 12-year-old, spayed female, Maltese dog with a round and firm mass on the dorsal part of the left rear paw and a cervical mass was brought to the clinic. The paw mass was contiguous to the adjacent tendon; it was composed of neoplastic mesenchymal cells and had scattered foci of calcification with chondroid differentiation microscopically. The neoplastic cells were positive for vimentin and S100, but negative for desmin and smooth muscle actin. Microscopic features and immunohistochemistry results were consistent with calcifying aponeurotic fibroma (CAF). The cervical mass was composed of polygonal cells forming acini with marked anisocytosis and anisokaryosis and diagnosed as thyroid follicular carcinoma. No recurrence or metastasis occurred during follow-up. To the best of our knowledge, this is the first case of canine CAF with features identical to its human counterparts. Key clinical message: This report describes the rare case of calcifying aponeurotic fibroma on the paw in a dog. This is apparently the first case in the veterinary literature with identical clinical and pathological features to the human counterpart.
一只 12 岁已绝育的雌性马尔济斯犬，左后脚背部有一个圆形且坚硬的肿块，颈部也有一个肿块。脚部肿块与相邻的肌腱相连；由间叶性肿瘤细胞组成，镜下可见散在的钙化灶并有软骨样分化。肿瘤细胞免疫组织化学结果显示波形蛋白和 S100 阳性，结蛋白和平滑肌肌动蛋白阴性。显微镜特征和免疫组织化学结果与钙化性腱膜纤维瘤（CAF）一致。颈部肿块由多边形细胞组成，形成有明显大小不均和核异型性的腺泡，诊断为甲状腺滤泡癌。随访期间无复发或转移。据我们所知，这是首例与人类 CAF 特征完全一致的犬 CAF 病例。关键临床信息：本报告描述了一例犬足部罕见的 CAF 病例。这显然是兽医文献中首例与人类 CAF 具有相同临床和病理特征的病例。
