Veterinary Medical Teaching Hospital, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 184-8602, Japan (Shimizu); Laboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 184-8602, Japan (Suzuki, Teshima, Matsumoto, Koyama); Keyaki Animal Hospital. 1-1-48-1F Tsuruse-higashi, Fujimi-shi, Saitama 354-0024, Japan (Ikeda); Faculty of Veterinary Medicine, Okayama University of Science, 1-3 Ikoinooka, Imabari-shi, Ehime 794-8555, Japan (Mochizuki); Laboratory of Veterinary Pathology, School of Veterinary Medicine, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 184-8602, Japan (Michishita).
Can Vet J. 2022 Feb;63(2):152-156.
A 6-month-old Shiba Inu dog was brought to the Veterinary Medical Teaching Hospital because of a cough, exercise intolerance, and pulmonary edema. The dog had a Levine 2/6 systolic murmur. Transthoracic echocardiography revealed left atrial and ventricular dilatation (left atrium to aortic ratio: 2.8), mitral and tricuspid valve regurgitation, and severe left ventricular myocardial hypokinesia (fractional shortening was 11.8%). Bubble contrast echocardiography did not reveal a congenital shunt; therefore, the dog was clinically diagnosed with early onset dilated cardiomyopathy. From the first visit, the dog was treated with pimobendan, taurine, torasemide, and isosorbide dinitrate. After 435 days, echocardiography revealed that systolic function had not improved. On Day 465, atrial fibrillation was confirmed electrocardiogram, and treatment with diltiazem hydrochloride was initiated. The dog continued to appear clinically stable thereafter, until it died suddenly 1087 days after the initial visit. A postmortem histopathological examination identified severe enlargement of the left atrial and ventricular chambers as well as attenuated wavy fibers in the ventricular myocardium, which confirmed dilated cardiomyopathy in a juvenile. This is the first report of a juvenile form of dilated cardiomyopathy in a Shiba Inu dog. This case report provides evidence that the extended prognosis of this dog differed from that in previously reported cases of dilated cardiomyopathy in young dogs. Key clinical message: This is the first reported case of a juvenile form of dilated cardiomyopathy in a Shiba Inu dog. This report provides evidence that the prognosis of this dog differed from that in previously reported cases of dilated cardiomyopathy in young dogs.
一只 6 月龄的柴犬因咳嗽、运动不耐受和肺水肿被带到兽医教学医院。该犬有 2/6 级 Levine 收缩期杂音。经胸超声心动图显示左心房和心室扩张（左心房与主动脉比值：2.8）、二尖瓣和三尖瓣反流以及严重的左心室心肌收缩无力（缩短分数为 11.8%）。微泡对比超声心动图未发现先天性分流；因此，临床诊断为早期扩张型心肌病。从首次就诊开始，该犬接受了匹莫苯丹、牛磺酸、托拉塞米和硝酸异山梨酯治疗。435 天后，超声心动图显示收缩功能没有改善。第 465 天，心电图证实发生了心房颤动，并开始使用盐酸地尔硫卓治疗。此后，该犬继续表现出临床稳定，直到在首次就诊后 1087 天突然死亡。尸检组织病理学检查发现左心房和心室腔明显扩大，心室心肌中的波纹纤维减弱，证实了幼犬扩张型心肌病。这是首例报道的柴犬幼年型扩张型心肌病病例。该病例报告提供了证据，表明该犬的预后与之前报道的年轻犬扩张型心肌病病例不同。关键临床信息：这是首例报道的柴犬幼年型扩张型心肌病病例。该报告提供了证据，表明该犬的预后与之前报道的年轻犬扩张型心肌病病例不同。
