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牙龈血管内皮瘤。组织病理学及治疗考量

Hemangioendothelioma of the gingiva. Histopathologic and therapeutic considerations.

作者信息

Ebo C M, de Boever J A, Adriaens P A, Roels H

出版信息

J Clin Periodontol. 1986 Jan;13(1):11-8. doi: 10.1111/j.1600-051x.1986.tb01408.x.

DOI:10.1111/j.1600-051x.1986.tb01408.x
PMID:3511101
Abstract

The hemangioendothelioma is a benign neoplasm, rarely observed in the mouth. In the literature, reports on the treatment and on the therapeutic results are lacking. This type of gingival neoplasm was observed in a young adult male. It was located in the attached gingiva in the upper and in the lower jaw, covering almost the entire coronal part of the anterior teeth. An exhaustive internal and neurological examination revealed no associated general disease. The gingival biopsies displayed the typical characteristics of a hemangioendothelioma: proliferation of the blood vessels, with a reduced lumen surrounded by swollen endothelial cells. The treatment consisted of a meticulous mechanical plaque control, chlorhexidine rinses, gingivectomy procedures and a monthly professional prophylaxis. 3 years after the periodontal treatment, the gingival structures remained clinically healthy. In the biopsies, only a small amount of inflammatory cells could be detected. This report shows a case of benign gingival neoplasms of unknown etiology in which meticulous plaque control, combined with extensive gingivectomies and repeated professional prophylaxis may have prevented or, at least, retarded the recurrence of the lesion.

摘要

血管内皮瘤是一种良性肿瘤,在口腔中很少见。文献中缺乏关于其治疗方法及治疗效果的报道。本文报道了一位年轻成年男性患者的此类牙龈肿瘤。肿瘤位于上下颌的附着龈,几乎覆盖了前牙的整个冠部。全面的内科和神经学检查未发现相关的全身性疾病。牙龈活检显示出血管内皮瘤的典型特征:血管增生,管腔变窄,周围内皮细胞肿胀。治疗方法包括细致的机械性菌斑控制、洗必泰漱口、牙龈切除术以及每月一次的专业预防措施。牙周治疗3年后,牙龈组织临床健康。活检显示仅能检测到少量炎性细胞。本报告展示了一例病因不明的良性牙龈肿瘤病例,其中细致的菌斑控制、广泛的牙龈切除术及反复的专业预防措施可能预防了或至少延缓了病变的复发。

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Cancers (Basel). 2021 Dec 9;13(24):6201. doi: 10.3390/cancers13246201.
2
Epithelioid hemangioendothelioma of the mandibular gingiva: A rare case of metastasis 4 years after radical excision and literature review.下颌牙龈上皮样血管内皮瘤:根治性切除4年后发生转移的罕见病例及文献复习
J Oral Maxillofac Pathol. 2016 Jan-Apr;20(1):137-41. doi: 10.4103/0973-029X.180975.
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Epithelioid hemangioendothelioma of the head and neck: role of podoplanin in the differential diagnosis.
头颈部上皮样血管内皮瘤:足板蛋白在鉴别诊断中的作用
Head Neck Pathol. 2008 Mar;2(1):25-30. doi: 10.1007/s12105-007-0035-0. Epub 2007 Oct 26.