Zhang Yun, Feng Yue, Zuo Jiacai, Shi Jian, Zhang Shanshan, Yang Yao, Xie Shu, Chen Zhonglun
Department of Neurology, Mianyang Central Hospital, Mianyang, China.
Department of Medical Laboratory, Mianyang Central Hospital, Mianyang, China.
Front Neurol. 2022 Jan 17;12:789204. doi: 10.3389/fneur.2021.789204. eCollection 2021.
The impact of serum amyloid A on cognitive impairment after ischemic stroke is unclear. We aimed to investigate the association between serum amyloid A (SAA) levels and post-stroke cognitive impairment (PSCI) at 3 months after ischemic stroke.
One hundred and ninety-eight patients were enrolled prospectively from June 2020 to April 2021. The SAA concentrations were measured using a commercially available enzyme-linked immunosorbent assay kit after admission. Cognitive function was assessed using the Montreal Cognitive Assessment score at 3 months after the symptom onset. We defined a Montreal Cognitive Assessment score <25 as cognitive impairment.
During 3-month follow-up, 80 patients (40.4%) were diagnosed as having PSCI. As compared with patients with cognitively normal ischemic stroke, those with PSCI were older, more likely to have diabetes and white matter lesions, and had a higher baseline National Institutes of Health stroke score and SAA levels. After adjustment for age, the National Institutes of Health stroke score and other covariates, the OR for the highest quartile of SAA compared with the lowest quartile was 5.72 (95% CI, 2.17-15.04, = 0.001) for PSCI. Also, ordinal logistic regression analysis showed that higher SAA concentrations were associated with increased risk of PSCI severity (OR, 4.31; 95% CI, 1.81-10.33, = 0.001). Similar results were found when the SAA levels were analyzed as a continuous variable.
This present study demonstrated that increased SAA levels might be associated with PSCI at 3 months after ischemic stroke.
血清淀粉样蛋白A对缺血性中风后认知障碍的影响尚不清楚。我们旨在研究缺血性中风后3个月时血清淀粉样蛋白A（SAA）水平与中风后认知障碍（PSCI）之间的关联。
2020年6月至2021年4月前瞻性纳入198例患者。入院后使用市售酶联免疫吸附测定试剂盒测量SAA浓度。症状发作后3个月使用蒙特利尔认知评估评分评估认知功能。我们将蒙特利尔认知评估评分<25定义为认知障碍。
在3个月的随访期间，80例患者（40.4%）被诊断为患有PSCI。与认知功能正常的缺血性中风患者相比，患有PSCI的患者年龄更大，更有可能患有糖尿病和白质病变，并且基线美国国立卫生研究院中风评分和SAA水平更高。在调整年龄、美国国立卫生研究院中风评分和其他协变量后，PSCI患者中SAA最高四分位数与最低四分位数相比的OR为5.72（95%CI，2.17 - 15.04，P = 0.001）。此外，有序逻辑回归分析表明，较高的SAA浓度与PSCI严重程度风险增加相关（OR，4.31；95%CI，1.81 - 10.33，P = 0.001）。将SAA水平作为连续变量分析时也发现了类似结果。
本研究表明，缺血性中风后3个月时SAA水平升高可能与PSCI有关。
