Wu Dan, Feng Mengyao, Shen Hongru, Shen Xilin, Hu Jiani, Liu Jilei, Yang Yichen, Li Yang, Yang Meng, Wang Wei, Zhang Qiang, Song Fangfang, Liu Ben, Chen Kexin, Li Xiangchun
National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Cancer Institute, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
Department of Epidemiology and Biostatistics, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
Front Genet. 2022 Jan 17;12:793494. doi: 10.3389/fgene.2021.793494. eCollection 2021.
Gastric cancer is the fifth most common type of human cancer and the third leading cause of cancer-related death. The purpose of this study is to investigate the immune infiltration signatures of gastric cancer and their relation to prognosis. We identified two distinct subtypes of gastric cancer (C1/C2) characterized by different immune infiltration signatures. C1 is featured by immune resting, epithelial-mesenchymal transition, and angiogenesis pathways, while C2 is featured by enrichment of the MYC target, oxidative phosphorylation, and E2F target pathways. The C2 subtype has a better prognosis than the C1 subtype (HR = 0.61, 95% CI: 0.44-0.85; log-rank test, = 0.0029). The association of C1/C2 with prognosis remained statistically significant (HR = 0.62, 95% CI: 0.44-0.87; = 0.006) after controlling for age, gender, and stage. The prognosis prediction of C1/C2 was verified in four independent cohorts (including an internal cohort). In summary, our study is helpful for better understanding of the association between immune infiltration and the prognosis of gastric cancer.
胃癌是人类第五大常见癌症类型，也是癌症相关死亡的第三大主要原因。本研究的目的是调查胃癌的免疫浸润特征及其与预后的关系。我们鉴定出了两种不同的胃癌亚型（C1/C2），其特征在于不同的免疫浸润特征。C1的特征是免疫静止、上皮-间质转化和血管生成途径，而C2的特征是MYC靶点、氧化磷酸化和E2F靶点途径的富集。C2亚型的预后比C1亚型更好（风险比=0.61，95%置信区间：0.44-0.85；对数秩检验，P=0.0029）。在控制年龄、性别和分期后，C1/C2与预后的关联仍具有统计学意义（风险比=0.62，95%置信区间：0.44-0.87；P=0.006）。C1/C2的预后预测在四个独立队列（包括一个内部队列）中得到了验证。总之，我们的研究有助于更好地理解免疫浸润与胃癌预后之间的关联。
