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以急性肝衰竭为表现的复发性髓外多发性骨髓瘤

Relapsing Extramedullary Multiple Myeloma Presenting As Acute Liver Failure.

作者信息

Javaid Hafiza Wajeeha, Munir Farrukh, Bahram Saman

机构信息

Internal Medicine, Wellspan York Hospital, York, USA.

Infectious Disease, University of Louisville, Louisville, USA.

出版信息

Cureus. 2021 Dec 28;13(12):e20786. doi: 10.7759/cureus.20786. eCollection 2021 Dec.

DOI:10.7759/cureus.20786
PMID:35111470
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8795222/
Abstract

Extramedullary spread of multiple myeloma was thought to be uncommon but with recent advancements in imaging and increased patient survival, the incidence of the extraosseous disease has risen in living individuals. Despite this, the extraosseous spread of multiple myeloma has been under-diagnosed and under-reported. Timely diagnosis of this extraosseous disease is clinically important, as it indicates a more aggressive disease variant and carries a poor prognosis.

摘要

多发性骨髓瘤的髓外扩散曾被认为并不常见,但随着近年来影像学的进步以及患者生存期的延长,骨外疾病在在世个体中的发病率有所上升。尽管如此,多发性骨髓瘤的骨外扩散一直存在诊断不足和报告不足的情况。及时诊断这种骨外疾病在临床上很重要,因为它表明疾病变体更具侵袭性且预后不良。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f51b/8795222/940cfecf0fd4/cureus-0013-00000020786-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f51b/8795222/9f08d6309632/cureus-0013-00000020786-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f51b/8795222/9c375842ac13/cureus-0013-00000020786-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f51b/8795222/940cfecf0fd4/cureus-0013-00000020786-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f51b/8795222/9f08d6309632/cureus-0013-00000020786-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f51b/8795222/9c375842ac13/cureus-0013-00000020786-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f51b/8795222/940cfecf0fd4/cureus-0013-00000020786-i03.jpg

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本文引用的文献

1
Multiple Extramedullary-Bone Related and/or Extramedullary Extraosseous Are Independent Poor Prognostic Factors in Patients With Newly Diagnosed Multiple Myeloma.多部位髓外骨相关和/或髓外骨外病变是新诊断多发性骨髓瘤患者独立的不良预后因素。
Front Oncol. 2021 Jul 7;11:668099. doi: 10.3389/fonc.2021.668099. eCollection 2021.
2
Expert review on soft-tissue plasmacytomas in multiple myeloma: definition, disease assessment and treatment considerations.多发性骨髓瘤中软组织浆细胞瘤的专家评论:定义、疾病评估和治疗考虑因素。
Br J Haematol. 2021 Aug;194(3):496-507. doi: 10.1111/bjh.17338. Epub 2021 Mar 16.
3
Extramedullary disease in multiple myeloma - controversies and future directions.
多发性骨髓瘤中的髓外疾病——争议与未来方向。
Blood Rev. 2019 Jul;36:32-39. doi: 10.1016/j.blre.2019.04.002. Epub 2019 Apr 13.
4
Rapidly changing myeloma epidemiology in the general population: Increased incidence, older patients, and longer survival.普通人群中骨髓瘤流行病学的快速变化:发病率上升、患者年龄增大以及生存期延长。
Eur J Haematol. 2018 Apr 20. doi: 10.1111/ejh.13083.
5
New Developments in Diagnosis, Prognosis, and Assessment of Response in Multiple Myeloma.多发性骨髓瘤诊断、预后及反应评估的新进展
Clin Cancer Res. 2016 Nov 15;22(22):5428-5433. doi: 10.1158/1078-0432.CCR-16-0866.
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MR imaging and PET/CT in diagnosis and management of multiple myeloma.磁共振成像和 PET/CT 在多发性骨髓瘤的诊断和治疗中的应用。
Radiographics. 2015 Mar-Apr;35(2):438-54. doi: 10.1148/rg.352140112.
7
Extramedullary involvement in multiple myeloma.多发性骨髓瘤的髓外浸润
Haematologica. 2012 Nov;97(11):1618-9. doi: 10.3324/haematol.2012.078519.
8
Multiple myeloma with rupture of ovarian plasmacytoma.多发性骨髓瘤伴卵巢浆细胞瘤破裂。
Chin Med J (Engl). 2012 Aug;125(16):2948-50.
9
Incidence of extramedullary disease in patients with multiple myeloma in the era of novel therapy, and the activity of pomalidomide on extramedullary myeloma.新型疗法时代多发性骨髓瘤患者发生髓外疾病的情况,以及泊马度胺对髓外骨髓瘤的作用。
Leukemia. 2011 Jun;25(6):906-8. doi: 10.1038/leu.2011.29. Epub 2011 Feb 25.
10
Cranial nerve palsy in multiple myeloma and solitary plasmacytoma.多发性骨髓瘤和孤立性浆细胞瘤中的颅神经麻痹
Asia Pac J Clin Oncol. 2010 Dec;6(4):251-5. doi: 10.1111/j.1743-7563.2010.01327.x. Epub 2010 Nov 3.