Department of Orthopedics, Lanzhou University Second Hospital, 82 Cuiying Men, Lanzhou, 730030, China.
Gansu Key Laboratory of Bone and Joint Diseases, Lanzhou, 730030, China.
Clin Transl Oncol. 2022 Jul;24(7):1274-1289. doi: 10.1007/s12094-022-02783-1. Epub 2022 Feb 2.
Ephrin receptor A7 (EphA7) is a member of the Eph receptor family. It is widely involved in signal transduction between cells, regulates cell proliferation and differentiation, and participates in developing neural tubes and brain. In addition, EphA7 also has a dual role of tumor promoter and tumor suppressor. It can participate in cell proliferation, migration and apoptosis through various mechanisms, and affect tumor differentiation, staging and prognosis. EphA7 may be a potential diagnostic marker and tumor treatment target. This article reviews the effects of EphA7 on a variety of tumor biological processes and pathological characteristics, as well as specific effects and regulatory mechanisms.
Ephrin 受体 A7（EphA7）是 Eph 受体家族的一员。它广泛参与细胞间的信号转导，调节细胞增殖和分化，并参与神经管和大脑的发育。此外，EphA7 还具有肿瘤促进因子和肿瘤抑制因子的双重作用。它可以通过多种机制参与细胞增殖、迁移和凋亡，并影响肿瘤的分化、分期和预后。EphA7 可能是一种潜在的诊断标志物和肿瘤治疗靶点。本文综述了 EphA7 对多种肿瘤生物学过程和病理特征的影响，以及其具体作用和调控机制。
