Biochemistry Department, Ekiti State University, Ado Ekiti, Nigeria.
Department of Biomedical Technology, Federal University of Technology, Akure, Nigeria.
J Food Biochem. 2022 Jul;46(7):e14100. doi: 10.1111/jfbc.14100. Epub 2022 Feb 2.
Cisplatin (CP) is a chemotherapeutic/anticancer drug culpable in sperm and testicular damage, but the use of dietary patterns has been reported to averse this effect. To date, no report on the use of roasted cashew nut-supplemented diets (RCNSD) against chemotherapy-induced testicular damage has been presented. In this study, the effect of 10% and 20% RCNSD on reproductive hormones, sperm parameters, testicular and epididymal antioxidant status, and steroidogenic enzymes activities in CP-induced rats were determined. Interestingly, these parameters were boosted, but with a decrement in radical species level in the testes/epididymis of CP-induced rats fed with RCNSD as against the untreated CP-induced rats. The modulatory effect of RCNSD on the tested reproductive parameters in studied tissues could be among the mechanism of action, by which RCNSD mitigates andrological toxicity. Hence, RCNSD could be harnessed as a functional food/nutraceutical agent for alleviating the andrological toxicity of CP-induced male reproduction. PRACTICAL APPLICATIONS: Consumption of cashew nuts has been a great benefit to human health, as a result of its richness in nutritional constituents including biologically active amino acids, tocopherols, fatty acids, polyphenols, and selenium, among others. Cashew nuts are mostly consumed fried/roasted, with yoghurt, as a paste, or used as an ingredient in confectionery products. The folkloric use of cashew nuts in the management of cardiovascular diseases, male reproductive disorders, and diabetes has been reported. In this study, the ability of roasted cashew nut-supplemented diets to modulate reproductive hormones, sperm parameters, testicular and epididymal antioxidant status, and steroidogenic enzymes activities in CP-induced reproductive toxicity in male rats was revealed, thus, indicating its possible use, clinically, in the management of reproductive toxicity induced by cancer drugs.
顺铂（CP）是一种化疗/抗癌药物，会导致精子和睾丸损伤，但有报道称，饮食模式可以减轻这种影响。迄今为止，尚无关于用烤腰果补充饮食（RCNSD）对抗化疗引起的睾丸损伤的报告。在这项研究中，确定了 10%和 20%RCNSD 对 CP 诱导的大鼠生殖激素、精子参数、睾丸和附睾抗氧化状态以及甾体生成酶活性的影响。有趣的是，与未用 RCNSD 处理的 CP 诱导的大鼠相比，用 RCNSD 喂养的 CP 诱导的大鼠的这些参数得到了提高，但睾丸/附睾中的自由基水平降低。RCNSD 对研究组织中测试生殖参数的调节作用可能是其减轻男性生殖毒理学作用的机制之一。因此，RCNSD 可以作为一种功能性食品/营养保健品，用于缓解 CP 诱导的男性生殖毒性。实际应用：腰果因其富含营养成分而对人类健康有益，包括生物活性氨基酸、生育酚、脂肪酸、多酚和硒等。腰果通常以油炸/烤制、与酸奶、作为糊状物或用作糖果产品的成分食用。腰果在管理心血管疾病、男性生殖障碍和糖尿病方面的民间用途已有报道。在这项研究中，揭示了烤腰果补充饮食调节 CP 诱导的雄性大鼠生殖毒性中生殖激素、精子参数、睾丸和附睾抗氧化状态以及甾体生成酶活性的能力，因此表明其在临床上可能用于管理癌症药物引起的生殖毒性。
