Fielder A R, Levene M I, Trounce J Q, Tanner M S
J R Soc Med. 1986 Jan;79(1):25-9. doi: 10.1177/014107688607900109.
Certain features of optic nerve hypoplasia (ONH), its systemic associations and investigation are exclusive to infancy. These include the facility to use cranial ultrasound, difficulties in assessing ocular features and visual function, and neonatal hypoglycaemia and jaundice. Six infants with ONH are presented; cerebral abnormalities were demonstrated by cranial ultrasound in five. Neonatal cholestatic jaundice and hypoglycaemia occurred in one infant. Two died and represent a group likely to remain undetected unless routine ophthalmic examination of neurologically abnormal neonates is undertaken. In infancy, both ocular and systemic aspects of ONH can be investigated simply and without sedation.
视神经发育不全（ONH）的某些特征、其全身关联及检查在婴儿期具有独特性。这些包括使用头颅超声的便利性、评估眼部特征和视觉功能的困难，以及新生儿低血糖和黄疸。本文介绍了6例患有ONH的婴儿；5例通过头颅超声显示有脑部异常。1例婴儿出现新生儿胆汁淤积性黄疸和低血糖。2例死亡，这代表了一个群体，除非对神经异常的新生儿进行常规眼科检查，否则他们可能仍未被发现。在婴儿期，可以简单且无需镇静地对视神经发育不全的眼部和全身方面进行检查。
