Pleckstrin homology-like domain family A, member 3, a miR-19a-3p-regulated gene, suppresses tumor growth in osteosarcoma by downregulating the Akt pathway.

Pleckstrin homology-like domain family A, member 3 (), is emerging as a critical regulator for multiple cancers. Nevertheless, the expression and role of in osteosarcoma remain unknown. Herein, we purposed to elucidate the role of in the progression and chemoresistance of osteosarcoma. According to the bioinformatics analysis, expression was low in osteosarcoma patients, and low content was linked to poor prognosis. Additionally, activation of suppressed osteosarcoma cell proliferation, migration, and chemoresistance, whereas inhibition caused the opposite effects. Mechanistically, our data revealed that negatively regulates the Akt/GSK3β signaling cascade in osteosarcoma. Furthermore, we found that miR-19a-3p might exert its oncogenic function by inhibiting expression in osteosarcoma. These results demonstrated miR-19a-3p/ / Akt/GSK3β axis has a pivotal role in osteosarcoma, and is a prospective therapeutic target for treating osteosarcoma.