Zhang Cui, Ma Xiufang, Cen Peipei, Yang Huifang, He Zixin, Guo Yan, Tian Danian, Liu Xiangyu
College of Public Health and Management, Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan 750021, China.
State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering, National Demonstration Center for Experimental Chemistry Education, College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, China.
Dalton Trans. 2022 Feb 22;51(8):3180-3187. doi: 10.1039/d2dt00051b.
Two novel dual-photosensitized stable complexes, namely [Eu(dpq)(BTFA)] (1) and [Tb(dpq)(BTFA)] (2), have been successfully assembled a mixed ligand approach using dipyrido[3,2-:2',3'-]quinoxaline (dpq) and 3-benzoyl-1,1,1-trifluoroacetone (BTFA). The crystallographic data reveal mononuclear lanthanide cores in both 1 and 2, in which each eight-coordinated Ln(III) ion is located in a slightly distorted dodecahedron (). The room-temperature photoluminescence spectra of complexes 1 and 2 indicate that both BTFA and dpq can effectively sensitize Eu(III) and Tb(III) characteristic luminescence. Moreover, heterometallic Ln-complexes can be synthesized, leading to a new series of differently doped EuxTb1-x complexes. Luminescence experiments on them reveal dual-emission peaks of Eu and Tb, which lead to a gradual change in the luminous colour between yellow-green, yellow, orange, orange-red and red upon increasing the Eu content. On the basis of the intrinsic strong emission properties and nontoxic nature of complexes 1 and 2, we explore their potential application as cellular imaging agents. Fluorescence microscopy data suggest the cytosolic and nuclear localization of 1 and 2 in HeLa and MCF-7 cells.
通过使用二吡啶并[3,2 - :2',3'-]喹喔啉（dpq）和3 - 苯甲酰基 - 1,1,1 - 三氟丙酮（BTFA）的混合配体方法，成功组装了两种新型的双光敏稳定配合物，即[Eu(dpq)(BTFA)]（1）和[Tb(dpq)(BTFA)]（2）。晶体学数据表明1和2中均为单核镧系元素核心，其中每个八配位的Ln(III)离子位于略微扭曲的十二面体中（）。配合物1和2的室温光致发光光谱表明，BTFA和dpq都能有效地敏化Eu(III)和Tb(III)的特征发光。此外，可以合成异金属Ln - 配合物，从而得到一系列新的不同掺杂的EuxTb1 - x配合物。对它们的发光实验揭示了Eu和Tb的双发射峰，随着Eu含量的增加，发光颜色在黄绿色、黄色、橙色、橙红色和红色之间逐渐变化。基于配合物1和2固有的强发射特性和无毒性质，我们探索了它们作为细胞成像剂的潜在应用。荧光显微镜数据表明1和2在HeLa和MCF - 7细胞中的胞质和核定位。
