血清神经丝轻链作为肝豆状核变性脑损伤的生物标志物：临床与神经影像学相关性研究。
Serum Neurofilament Light Chain as a Biomarker of Brain Injury in Wilson's Disease: Clinical and Neuroradiological Correlations.
机构信息
Center of Clinical Neuroscience, Department of Neurology, University Clinic Carl Gustav Carus & Dresden University of Technology, Dresden, Germany.
Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland.
出版信息
Mov Disord. 2022 May;37(5):1074-1079. doi: 10.1002/mds.28946. Epub 2022 Feb 3.
BACKGROUND
Clinical scales and neuroimaging are used to monitor nervous system injury in Wilson's disease, while data on serum markers are scarce.
OBJECTIVE
To investigate whether serum concentrations of neurofilament light chain (sNfL) correlate with brain injury in Wilson's disease patients.
METHODS
In 61 treatment-naïve patients, the Unified Wilson's Disease Rating Scale and a validated semiquantitative brain magnetic resonance imaging scale were compared with concentrations of sNfL.
RESULTS
Concentrations of sNfL were significantly higher in patients with neurological disease compared with patients presenting with other forms (39.7 ± 73.4 pg/mL vs. 13.3 ± 9.2 pg/mL; P < 0.01). Moreover, the sNfL concentration positively correlated with neurological severity scores and with acute and chronic brain damage based on the neuroimaging scale.
CONCLUSIONS
Neurofilament light chain concentrations may be used as a marker of brain injury in Wilson's disease, in addition to the clinical and neuroimaging disease severity scales. © 2022 International Parkinson and Movement Disorder Society.
背景
临床量表和神经影像学用于监测威尔逊病中的神经系统损伤，而血清标志物的数据则很少。
目的
研究血清神经丝轻链（sNfL）浓度是否与威尔逊病患者的脑损伤相关。
方法
在 61 例未经治疗的初治患者中，将统一的威尔逊病评分量表和经过验证的半定量脑磁共振成像量表与 sNfL 浓度进行比较。
结果
与其他形式的疾病相比，神经疾病患者的 sNfL 浓度明显更高（39.7±73.4 pg/mL 比 13.3±9.2 pg/mL；P<0.01）。此外，sNfL 浓度与神经影像学量表上的神经严重程度评分以及急性和慢性脑损伤呈正相关。
结论
除了临床和神经影像学疾病严重程度量表外，神经丝轻链浓度还可以作为威尔逊病脑损伤的标志物。
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