Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark.
Department of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark.
APMIS. 2022 May;130(5):253-260. doi: 10.1111/apm.13212. Epub 2022 Feb 28.
The water channel aquaporin-5 (AQP5) is essential in transepithelial water transport in secretory glands. AQP5 is ectopically overexpressed in breast cancer, where expression is associated with lymph node metastasis and poor prognosis. Besides the role in water transport, AQP5 has been found to play a role in cancer metastasis, migration, and proliferation. AQP5 has also been shown to be involved in the dysregulation of epithelial cell-cell adhesion; frequently observed in cancers. Insight into the underlying molecular mechanisms of how AQP5 contributes to cancer development and progression is essential for potentially implementing AQP5 as a prognostic biomarker and to develop targeted intervention strategies for the treatment of breast cancer patients.
水通道蛋白 aquaporin-5（AQP5）对于分泌腺的跨上皮水转运至关重要。AQP5 在乳腺癌中过表达，其表达与淋巴结转移和预后不良相关。除了在水转运中的作用外，AQP5 还被发现与癌症转移、迁移和增殖有关。AQP5 还被证明参与了上皮细胞-细胞黏附的失调；这种失调在癌症中经常观察到。深入了解 AQP5 如何促进癌症发展和进展的潜在分子机制，对于将 AQP5 作为预后生物标志物并开发针对乳腺癌患者的靶向干预策略至关重要。
