Durelli L, Cocito D, Riccio A, Barile C, Bergamasco B, Baggio G F, Perla F, Delsedime M, Gusmaroli G, Bergamini L
Neurology. 1986 Feb;36(2):238-43. doi: 10.1212/wnl.36.2.238.
We conducted a double-blind trial of high-dose parenteral 6-methylprednisolone (MP) and placebo on 23 patients with acute MS. After the double-blind trial, the patients were given corticosteroids in gradually decreasing doses. The frequency of improvement was significantly higher and the bout duration significantly lower in the MP group than in the placebo group. The first signs of improvement (3 to 6 days after starting MP) were associated with a marked decrease in the rate of CNS IgG synthesis, but IgG CSF oligoclonal bands did not change. CNS IgG production slowly returned toward baseline despite progressive clinical improvement.
我们对23例急性多发性硬化症（MS）患者进行了高剂量肠外注射6-甲基泼尼松龙（MP）和安慰剂的双盲试验。双盲试验结束后，给予患者逐渐减量的皮质类固醇。MP组的改善频率显著高于安慰剂组，发作持续时间显著短于安慰剂组。改善的最初迹象（开始使用MP后3至6天）与中枢神经系统（CNS）IgG合成率的显著降低有关，但脑脊液IgG寡克隆带没有变化。尽管临床持续改善，但中枢神经系统IgG产生仍缓慢恢复至基线水平。
