静脉注射甲基泼尼松龙与促肾上腺皮质激素治疗多发性硬化急性复发的相对疗效
Relative efficacy of intravenous methylprednisolone and ACTH in the treatment of acute relapse in MS.
作者信息
Thompson A J, Kennard C, Swash M, Summers B, Yuill G M, Shepherd D I, Roche S, Perkin G D, Loizou L A, Ferner R
机构信息
Department of Neurology, London Hospital, UK.
出版信息
Neurology. 1989 Jul;39(7):969-71. doi: 10.1212/wnl.39.7.969.
To compare the efficacy of high-dose intravenous methylprednisolone with intramuscular ACTH in the treatment of acute relapse in multiple sclerosis, we undertook a double-blind, randomized, controlled study involving 61 patients. There was a marked improvement in both groups in the course of the study, but no difference between them in either the rate of recovery or the final outcome. High-dose IV methylprednisolone is a safe alternative to ACTH in the management of acute relapse in MS.
为比较大剂量静脉注射甲基泼尼松龙与肌内注射促肾上腺皮质激素（ACTH）治疗多发性硬化急性复发的疗效，我们进行了一项双盲、随机、对照研究，涉及61例患者。在研究过程中两组均有显著改善，但在恢复率或最终结局方面两组之间无差异。在多发性硬化急性复发的治疗中，大剂量静脉注射甲基泼尼松龙是ACTH的一种安全替代药物。
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