Ojinmed IVF Center, Ulaanbaatar, Mongolia.
Ojinmed IVF Center, Ulaanbaatar, Mongolia.
Reprod Biol. 2022 Mar;22(1):100596. doi: 10.1016/j.repbio.2021.100596. Epub 2022 Jan 31.
Selection of best blastocyst is crucial in single blastocyst transfer cycles, which is based on blastocyst morphological parameters such as inner cell mass (ICM), trophectoderm (TE) and its inner diameter. We aimed to study relation between morphological parameter and sex ratio after single vitrified-warmed blastocyst transfer (SVBT). Current study based on data of single-center and performed by retrospective analysis of 1563 SVBT (911 patients) with minimal stimulation on 5th and 6th days. TE morphology, female age and blastocyst day are highly correlated with clinical pregnancy rate (CPR) and live birth rate (LBR). Also, A grade ICM significantly correlated with CPR than C grade. Additionally, probability of being male gender is 2.8 times higher in singleton live birth with A grade trophectoderm than C grade. Neither ICM morphology, LBR nor sex ratio were not related to trophoectoderm grade. Higher grade TE, younger the age of patient and selection of the day 5 blastocyst showed higher frequency of CPR and LBR. Therefore, consideration of these parameters is a better method to select the best embryo. On the other hand, the selection for transfer blastocyst based on quality and morphological parameters may inadvertently push the secondary sex ratio (SSR) in favor of female births.
选择最佳的囊胚在单囊胚移植周期中至关重要，这是基于囊胚形态学参数，如内细胞团（ICM）、滋养外胚层（TE）及其内径。我们旨在研究单囊胚玻璃化冷冻解冻移植（SVBT）后形态学参数与性别比例的关系。本研究基于单中心数据，通过对 5 天和 6 天进行最小刺激的 1563 例 SVBT（911 例患者）进行回顾性分析。TE 形态、女性年龄和囊胚天数与临床妊娠率（CPR）和活产率（LBR）高度相关。此外，A级 ICM 与 CPR 的相关性明显高于 C 级。此外，A级滋养外胚层的单胎活产儿中男性的概率比 C 级高 2.8 倍。ICM 形态、LBR 或性别比例与滋养外胚层等级均无关。较高等级的 TE、患者年龄较小以及选择第 5 天的囊胚显示出更高的 CPR 和 LBR 频率。因此，考虑这些参数是选择最佳胚胎的更好方法。另一方面，基于质量和形态学参数选择用于移植的囊胚可能会无意中推动次要性别比例（SSR）有利于女性出生。
