2-甲基-3,3-二苯基-3-丙醇胺（2-MDP）选择性拮抗N-甲基天冬氨酸（NMA）。

2-Methyl-3,3-diphenyl-3-propanolamine (2-MDP) selectively antagonises N-methyl-aspartate (NMA).

作者信息

Blake J C, Davies S N, Church J, Martin D, Lodge D

出版信息

Pharmacol Biochem Behav. 1986 Jan;24(1):23-5. doi: 10.1016/0091-3057(86)90038-9.

Abstract

Using electrophoretic application to rat central neurones in vivo, and bath application to frog spinal cord in vitro, 2-methyl-3,3-diphenyl-3-propanolamine was found to be a selective antagonist of N-methyl-DL-aspartate, but not of quisqualate or kainate. In this respect the (-) isomer proved to be about three times more potent than the (+) in both preparations.

摘要

通过对大鼠体内中枢神经元进行电泳给药以及对青蛙离体脊髓进行浴槽给药，发现2-甲基-3,3-二苯基-3-丙醇胺是N-甲基-DL-天冬氨酸的选择性拮抗剂，但不是喹啉酸或红藻氨酸的拮抗剂。在这方面，（-）异构体在两种制剂中的效力比（+）异构体高约三倍。