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基于液滴的微流控技术在制备微粒中的应用。

Use of droplet-based microfluidic techniques in the preparation of microparticles.

出版信息

Ceska Slov Farm. 2021 Winter;70(5):155-163. doi: 10.5817/CSF2021-5-155.

Abstract

Microparticles are widely used in myriad fields such as pharmaceuticals, foods, cosmetics, and other industrial fields. Compared with traditional methods for synthesizing microparticles, microfluidic techniques provide very powerful platforms for creating highly controllable emulsion droplets as templates for fabricating uniform microparticles with advanced structures and functions. Microfluidic techniques can generate emulsion droplets with precisely controlled size, shape, and composition. A more precise preparation process brings an effective tool to control the release profile of the drug and introduces an easily accessible reproducibility. The paper gives information about basic droplet-based set-ups and examples of attainable microparticle types preparable by this method.

摘要

微球在制药、食品、化妆品和其他工业领域得到了广泛的应用。与传统的微球合成方法相比,微流控技术为制备具有先进结构和功能的均匀微球提供了非常强大的乳液滴模板合成平台。微流控技术可以生成具有精确控制的尺寸、形状和组成的乳液滴。更精确的制备过程为控制药物的释放特性提供了有效的工具,并引入了易于重现的方法。本文介绍了基于液滴的基本装置信息和通过该方法可制备的微球类型示例。

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