Morantz R A, Shain W, Cravioto H
J Neurosurg. 1978 Jul;49(1):84-92. doi: 10.3171/jns.1978.49.1.0084.
The theory of immune surveillance postulates that one function of the immune system is to eliminate small numbers of malignant cells that arise spontaneously within the organism. Although there has been a great deal of both clinical and experimental evidence in favor of thistheory as it applies to general oncology, the question of whether or not such a surveillance system would be effective for tumors arising within the nervous system has never been studied. The young of pregnant rats which had been exposed to the neurocarcinogen ethylnitrosourea (ENU) were divided into control, immunosuppressed, and immunoenhanced groups. These lifetime alterations of the immune system had no effect on the course of nervous system tumor fromation. We believe that the most likely explanation for our results is that the "immunological privilege" of the brain prevents the usual interaction of the neoplasm and the immune system from occurring.
免疫监视理论假定，免疫系统的一个功能是清除机体内自发产生的少量恶性细胞。尽管有大量临床和实验证据支持该理论在普通肿瘤学中的应用，但这样一个监视系统对神经系统内产生的肿瘤是否有效这一问题从未得到研究。将暴露于神经致癌物乙基亚硝基脲（ENU）的怀孕大鼠的幼崽分为对照组、免疫抑制组和免疫增强组。免疫系统的这些终生改变对神经系统肿瘤形成的过程没有影响。我们认为，对我们结果最可能的解释是，大脑的“免疫豁免权”阻止了肿瘤与免疫系统之间正常相互作用的发生。
