Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Atherosclerosis. 2022 Mar;345:44-50. doi: 10.1016/j.atherosclerosis.2022.01.014. Epub 2022 Jan 24.
High-density lipoprotein (HDL) functionality is an important determinant of coronary artery disease (CAD) development. We recently developed cholesterol-uptake capacity (CUC), a rapid cell-free assay system that directly evaluates the capacity of HDL to accept additional cholesterol. We aimed to evaluate the association between CUC and revascularization in patients who have undergone percutaneous coronary intervention (PCI).
We retrospectively reviewed patients who underwent PCI with subsequent revascularization or coronary angiography (CAG) without revascularization. The patients who had frozen blood samples for which CUC were measurable at the index PCI and follow-up were enrolled.
We finally enrolled 74 patients who underwent subsequent revascularization and 183 patients who underwent follow-up CAG without revascularization. The serum CUC level at the index PCI was significantly lower in the revascularization group than that in the non-revascularization group (84.3 [75.2-98.9] vs. 92.0 [81.6-103.3 A U.]; p = 0.004). Multivariate logistic regression analysis revealed that decreased serum CUC level at the index PCI was independently associated with subsequent revascularization (odds ratio, 0.98; 95% confidence interval, 0.969-1.000). After adjusting for 16 cardiovascular risk factors, the serum CUC level at the index PCI and follow-up and the absolute change in serum CUC level from the index PCI to follow-up were significantly lower in the revascularization group than those in the non-revascularization group.
Serum CUC level at index PCI was independently associated with subsequent revascularization after PCI. Continuous assessment of HDL functionality by CUC might help predict subsequent revascularization after PCI.
高密度脂蛋白（HDL）功能是冠心病（CAD）发展的一个重要决定因素。我们最近开发了胆固醇摄取能力（CUC），这是一种快速的无细胞检测系统，可以直接评估 HDL 接受额外胆固醇的能力。我们旨在评估接受经皮冠状动脉介入治疗（PCI）的患者的 CUC 与血运重建之间的关联。
我们回顾性地审查了接受 PCI 后进行血运重建或冠状动脉造影（CAG）而未进行血运重建的患者。招募了在索引 PCI 和随访时可测量 CUC 的冷冻血样的患者。
我们最终纳入了 74 例接受后续血运重建的患者和 183 例接受无血运重建的随访 CAG 的患者。血运重建组的 CUC 水平在索引 PCI 时明显低于无血运重建组（84.3 [75.2-98.9] vs. 92.0 [81.6-103.3 A.U.]；p=0.004）。多变量逻辑回归分析显示，指数 PCI 时血清 CUC 水平降低与随后的血运重建独立相关（比值比，0.98；95%置信区间，0.969-1.000）。在调整了 16 个心血管危险因素后，血运重建组的 CUC 水平在索引 PCI 和随访时以及从索引 PCI 到随访时的血清 CUC 水平的绝对变化明显低于无血运重建组。
指数 PCI 时的血清 CUC 水平与 PCI 后血运重建独立相关。通过 CUC 连续评估 HDL 功能可能有助于预测 PCI 后血运重建。
