斑马鱼与特发性脊柱侧凸：“未知的已知”。
Zebrafish and idiopathic scoliosis: the 'unknown knowns'.
机构信息
Department of Orthopedics, Capital Medical University, Beijing, China; Department of Orthopedic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
出版信息
Trends Genet. 2022 Jun;38(6):524-528. doi: 10.1016/j.tig.2022.01.002. Epub 2022 Jan 31.
The etiology and heterogeneity of idiopathic scoliosis (IS) are poorly understood. Studies using scoliotic zebrafish models have indicated a potential link between ciliary defects and scoliosis. They may further explain the onset of IS partially. However, it is necessary to further interpret the link between this progress and clinical medicine.
特发性脊柱侧凸（IS）的病因和异质性尚不清楚。使用脊柱侧凸斑马鱼模型的研究表明，纤毛缺陷与脊柱侧凸之间可能存在潜在联系。它们可能部分解释了 IS 的发病机制。然而，有必要进一步解释这一进展与临床医学之间的联系。
Zotero 插件