O'Donnell D, Seggie J, Levinson I, Meyers A M, Botha J R, Myburgh J A, Cohen M, Duff J H, Thorsell R
S Afr Med J. 1986 Feb 1;69(3):177-9.
Thirty-three living related kidney donors were investigated at a mean of 5.8 years after donor nephrectomy (range 3-18 years) to detect late adverse effects. They were evaluated for hypertension, the presence of proteinuria and renal dysfunction as assessed by serum creatinine value and creatinine clearance. There was a significant rise in both diastolic blood pressure and serum creatinine levels and a trend towards significance in the decline in creatinine clearance. Eleven individuals had diastolic blood pressure greater than or equal to 90 mmHg but only 1 required treatment. Although the rise in serum creatinine reached significance the mean serum creatinine (104.91 mumol/l) remained within the normal range. Two patients showed a minimal rise in proteinuria. The overall results confirm that kidney donation is safe and indicate that there are no significant late sequelae.
对33名活体亲属肾供体在供肾切除术后平均5.8年（范围3 - 18年）进行调查，以检测晚期不良反应。评估他们是否患有高血压、蛋白尿情况以及通过血清肌酐值和肌酐清除率评估的肾功能障碍。舒张压和血清肌酐水平均显著升高，肌酐清除率下降有显著趋势。11名个体舒张压大于或等于90 mmHg，但只有1人需要治疗。尽管血清肌酐升高达到显著水平，但平均血清肌酐（104.91μmol/l）仍在正常范围内。两名患者蛋白尿有轻微升高。总体结果证实肾捐赠是安全的，且表明没有明显的晚期后遗症。
