van Leeuwen W J, Guinée P A, Voogd C E, van Klingeren B
Tijdschr Diergeneeskd. 1986 Jan 1;111(1):9-13.
Approximately 20,000 strains of Salmonella were screened annually for resistance to tetracycline, chloramphenicol, kanamycin and ampicillin since 1959, and also to trimethoprim since 1978. Tetracycline-resistant strains increased in human subjects and pigs from 1961. After the ban on incorporation of tetracycline in animal feeds for nutritive purposes in 1974, the proportion of tetracycline-resistant strains in pigs and human subjects decreased. In veal calves, the number of strains of S. typhimurium and S. dublin resistant to multiple drugs increased from 1972. Strains resistant to multiple antibiotics in man were mainly isolated from adoptive children from Indonesia. No further spread of these strains was observed. So far, strains similar to those in calves resistant to multiple drugs were only incidentally isolated from human patients.
自1959年起,每年对约20000株沙门氏菌进行四环素、氯霉素、卡那霉素和氨苄西林耐药性筛查,自1978年起还进行甲氧苄啶耐药性筛查。1961年起,人体和猪体内对四环素耐药的菌株有所增加。1974年禁止在动物饲料中添加四环素用作营养目的后,猪和人体中对四环素耐药菌株的比例有所下降。在犊牛中,鼠伤寒沙门氏菌和都柏林沙门氏菌对多种药物耐药的菌株数量自1972年起增加。人体中对多种抗生素耐药的菌株主要从印度尼西亚收养儿童中分离得到。未观察到这些菌株的进一步传播。迄今为止,与犊牛中对多种药物耐药的菌株相似的菌株仅偶尔从人类患者中分离得到。