School of Stomatology, Henan University, Kaifeng, Henan 475004, China.
Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China.
Oxid Med Cell Longev. 2022 Jan 25;2022:1886277. doi: 10.1155/2022/1886277. eCollection 2022.
Oral diseases are among the most common human diseases yet less studied. These diseases affect both the physical, mental, and social health of the patients resulting in poor quality of life. They affect all ages, although severe stages are mostly observed in older individuals. Poor oral hygiene, genetics, and environmental factors contribute enormously to the development and progression of these diseases. Although there are available treatment options for these diseases, the recurrence of the diseases hinders their efficiency. Oral volatile sulfur compounds (VSCs) are highly produced in oral cavity as a result of bacteria activities. Together with bacteria components such as lipopolysaccharides, VSCs participate in the progression of oral diseases by regulating cellular activities and interfering with the immune response. Hydrogen sulfide (HS) is a gaseous neurotransmitter primarily produced endogenously and is involved in the regulation of cellular activities. The gas is also among the VSCs produced by oral bacteria. In numerous diseases, HS have been reported to have dual effects depending on the cell, concentration, and donor used. In oral diseases, high production and subsequent utilization of this gas have been reported. Also, this high production is associated with the progression of oral diseases. In this review, we will discuss the production of HS in oral cavity, its interaction with cellular activities, and most importantly its role in oral diseases.
口腔疾病是最常见的人类疾病之一，但研究较少。这些疾病影响患者的身心健康和社会健康，导致生活质量下降。它们影响所有年龄段的人，尽管严重阶段主要发生在老年人身上。不良的口腔卫生、遗传和环境因素对这些疾病的发展和进展有很大的影响。尽管这些疾病有可用的治疗方法，但疾病的复发阻碍了它们的效率。口腔挥发性硫化合物 (VSCs) 是由于细菌活动而在口腔中大量产生的。VSCs 与细菌成分（如脂多糖）一起，通过调节细胞活动和干扰免疫反应来参与口腔疾病的进展。硫化氢 (HS) 是一种主要由内源性产生的气态神经递质，参与细胞活动的调节。该气体也是口腔细菌产生的 VSCs 之一。在许多疾病中，HS 已被报道具有双重作用，具体取决于细胞、浓度和使用的供体。在口腔疾病中，已报道这种气体的高产量和随后的利用。此外，这种高产量与口腔疾病的进展有关。在这篇综述中，我们将讨论 HS 在口腔中的产生、它与细胞活动的相互作用，以及最重要的是它在口腔疾病中的作用。
