Department of Restorative Dentistry and Endodontics, Semmelweis University, Budapest, Hungary.
Centre for Translational Medicine, Semmelweis University, Budapest, Hungary.
PLoS One. 2023 Jan 12;18(1):e0280377. doi: 10.1371/journal.pone.0280377. eCollection 2023.
We aimed to conduct a systematic review on published data in order to investigate the efficacy of mouthwash products containing chlorine dioxide in halitosis.
Systematic review and meta-analysis.
Our search was conducted on 14th October 2021. We searched the following electronic databases: MEDLINE, Embase, Scopus, Web of Science, and CENTRAL. We analysed data on adults with halitosis, included only randomised controlled trials and excluded in vitro and animal studies. The interventional groups used chlorine dioxide, and the comparator groups used a placebo or other mouthwash. Our primary outcomes were changes in organoleptic test scores (OLS) and Volatile Sulfur Compound (VSC) levels from baseline to the last available follow-up.
We found 325 articles in databases. After the selection process, ten articles were eligible for qualitative synthesis, and 7 RCTs with 234 patients were involved in the meta-analysis. Our findings showed a significant improvement in the parameters of the chlorine dioxide group compared to the placebo group in OLS one-day data (mean difference (MD): -0.82; 95% confidence intervals (95% CIs): [-1.04 --0.6]; heterogeneity: I2 = 0%, p = 0.67); and one-week OLS data (MD: -0.24; 95% CIs: [-0.41 --0.07]; I2 = 0%, p = 0.52); and also changes in H2S one-day data (standardised mean difference (SMD): -1.81; 95% CIs: [-2.52 --1.10]); I2 = 73.4%, p = 0.02).
Our data indicate that chlorine dioxide mouthwash may be a good supportive therapy in oral halitosis without known side effects.
系统评价已发表数据，以评估含二氧化氯的漱口液产品治疗口臭的疗效。
系统评价和荟萃分析。
检索日期为 2021 年 10 月 14 日，检索了 MEDLINE、Embase、Scopus、Web of Science 和 CENTRAL 等电子数据库。分析纳入了成人口臭患者的随机对照试验，排除了体外和动物研究。干预组使用二氧化氯，对照组使用安慰剂或其他漱口液。主要结局为基线至最后一次随访时感官测试评分（OLS）和挥发性硫化物（VSC）水平的变化。
数据库中检索到 325 篇文章。经过筛选流程，10 篇文章纳入定性分析，7 项 RCT 共 234 例患者纳入荟萃分析。结果显示，与安慰剂组相比，二氧化氯组 OLS 一日数据（均数差（MD）：-0.82；95%置信区间（95%CI）：[-1.04 --0.6]；异质性：I2 = 0%，p = 0.67）和一周 OLS 数据（MD：-0.24；95%CI：[-0.41 --0.07]；I2 = 0%，p = 0.52）以及 H2S 一日数据（标准化均数差（SMD）：-1.81；95%CI：[-2.52 --1.10]）的改善更为显著，I2 = 73.4%，p = 0.02）。
我们的数据表明，二氧化氯漱口液可能是一种治疗口腔口臭的有效辅助治疗方法，且无已知副作用。
