Lieberman J A, Kane J M, Reife R
Adv Neurol. 1986;43:231-49.
The MAOI class of drugs is known to produce neuromuscular effects at therapeutic and toxic doses when given alone or in combination with other drugs. These effects range from muscle tension and twitches in their mild form to forceful myoclonic jerks. These effects may also be part of a more pervasive toxic syndrome that includes autonomic and mental symptoms as well. There is meager direct and substantial indirect evidence that serotonergic mechanisms play a role in mediating the neuromuscular effects of MAOIs. We have hypothesized that MAOIs produce a condition of heightened neuromuscular excitability due to a combination of increased serotonergic tone and central disinhibition of alpha-motor neuron-mediated spinal activity. Further study is needed utilizing objective pharmacologic and neurophysiologic measures.
已知单胺氧化酶抑制剂（MAOI）类药物单独使用或与其他药物联合使用时，在治疗剂量和中毒剂量下都会产生神经肌肉效应。这些效应从轻微的肌肉紧张和抽搐到剧烈的肌阵挛性抽搐不等。这些效应也可能是更广泛的中毒综合征的一部分，该综合征还包括自主神经和精神症状。有少量直接证据和大量间接证据表明，血清素能机制在介导MAOI的神经肌肉效应中起作用。我们推测，由于血清素能张力增加和α运动神经元介导的脊髓活动的中枢去抑制作用相结合，MAOI会导致神经肌肉兴奋性增强。需要利用客观的药理学和神经生理学测量方法进行进一步研究。
