Bhatia B, Koppitch F C, Sokol R J, Evans M I
Am J Obstet Gynecol. 1986 Feb;154(2):408-11. doi: 10.1016/0002-9378(86)90680-0.
Low cytogenetic yields in the processing of small chorionic villus sampling have in some instances, limited its applicability. We have modified "standard" techniques to increase the number of interpretable metaphases by (1) using a gravity method for cell suspension spreading and (2) using a special high-quality slide glass. Both modifications reduce cell damage and increase interpretable mitotic figures and may allow a cytogenetic diagnosis in some instances in which a diagnosis might not otherwise be possible with standard methods.
在处理小绒毛取样时，细胞遗传学产出率较低，在某些情况下限制了其适用性。我们改进了“标准”技术，通过（1）使用重力法进行细胞悬液铺展和（2）使用特殊的高质量载玻片，来增加可解读中期分裂相的数量。这两种改进都减少了细胞损伤，增加了可解读的有丝分裂图像，并且在某些情况下，可能允许进行细胞遗传学诊断，而使用标准方法可能无法做出诊断。
