Chen Jiali, Shen Chunying, Hu Chaosu, Wang Cuihong, Zhu Yongxue, Lu Xueguan
Department of Head & Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Transl Cancer Res. 2020 Jan;9(1):240-248. doi: 10.21037/tcr.2019.12.81.
The purpose was to investigate the prognosis of patients with synchronous and metachronous squamous cell carcinoma of head and neck (HNSCC) and esophagus (ESCC), and to evaluate the prognostic factors of these patients.
A retrospective review was performed on 70 patients with synchronous and metachronous HNSCC and ESCC treated in our institution from January 2005 to December 2016. Kaplan-Meier method and Cox proportional hazard model were used to evaluate overall survival (OS) and determine the prognostic factors associated with survival outcomes.
The 1-, 2- and 3-year OS rates were 77.1%, 57.1% and 37.1% with the median survival time for 33.5 months. The univariate analysis results revealed that the patients with early-stage of ESCC, metachronous cancer, and receiving surgery for both cancer had better OS (P=0.003; P=0.035; P=0.002). The multivariate analysis showed that the clinical stage of ESCC and receiving surgery for both cancer or not were the independent prognostic factors for OS.
The multidisciplinary treatment outcome is acceptable, especially for patients with early clinical stage ESCC and with chance to receiving surgery for both cancer.
目的是研究头颈部鳞状细胞癌（HNSCC）和食管癌（ESCC）同时性和异时性患者的预后，并评估这些患者的预后因素。
对2005年1月至2016年12月在本机构接受治疗的70例HNSCC和ESCC同时性和异时性患者进行回顾性分析。采用Kaplan-Meier法和Cox比例风险模型评估总生存期（OS），并确定与生存结果相关的预后因素。
1年、2年和3年总生存率分别为77.1%、57.1%和37.1%，中位生存时间为33.5个月。单因素分析结果显示，ESCC早期、异时性癌以及两种癌症均接受手术治疗的患者总生存期较好（P = 0.003；P = 0.035；P = 0.002）。多因素分析表明，ESCC的临床分期以及是否接受两种癌症的手术治疗是总生存期的独立预后因素。
多学科治疗效果可接受，特别是对于ESCC临床早期且有机会接受两种癌症手术治疗的患者。
