癌症患者组织中唾液酸化-Tn表达临床生存意义的系统评价与荟萃分析
Systematic review and meta-analysis of the clinical survival significance of Sialyl-Tn expression in histological tissues from cancer patients.
作者信息
Lugo Roberto, Ávila-Nava Azalia, García-Pérez Rodrigo, Herrera-Escalante Sarahí, De la Cruz-Acosta Jocelyne, Gutiérrez-Solis Ana Ligia
机构信息
Regional High Speciality Hospital of the Yucatan Peninsula, Merida, Yucatan, México.
出版信息
Transl Cancer Res. 2020 Feb;9(2):547-555. doi: 10.21037/tcr.2019.11.53.
BACKGROUND
The expression of Sialyl-Tn (STn) has been associated with different mechanisms of cancer. Several studies using histological tissue samples from different types of cancer showed differences in the STn expression patterns, but few studies have explored the association between STn expression and decreased overall survival. Therefore, a comprehensive analysis of the clinical significance of STn in cancer patients was performed.
METHODS
A systematic review and meta-analysis were done of scientific articles published and available from different sources, including MEDLINE/PubMed, Web of Science, Cochrane Library and LILACS. Odds ratio (OR) was represented by the number of deaths during follow-up in positive-STn versus negative-STn patients. OR from each study was pooled and the results were presented in a forest plot.
RESULTS
Eleven articles were included in the systematic meta-analysis. The estimated OR of 3.26 (95% CI: 2.12-5.02) was obtained. Furthermore, subgroups studies of gastric cancer showed an OR of 3.74 (95% CI: 2.47-5.66) and other cancer types reported an OR of 2.92 (95% CI: 1.16-7.32).
CONCLUSIONS
This study showed that survival time was significantly longer in patients with negative-STn tumors than in those with positive results.
背景
唾液酸-Tn（STn）的表达与癌症的不同机制有关。多项使用不同类型癌症组织学样本的研究显示了STn表达模式的差异，但很少有研究探讨STn表达与总生存期降低之间的关联。因此，对癌症患者中STn的临床意义进行了全面分析。
方法
对从不同来源（包括MEDLINE/PubMed、科学网、考克兰图书馆和拉丁美洲及加勒比卫生科学数据库）发表并可获取的科学文章进行系统综述和荟萃分析。比值比（OR）用STn阳性患者与STn阴性患者随访期间的死亡人数表示。汇总每项研究的OR，并将结果呈现于森林图中。
结果
11篇文章纳入了系统荟萃分析。获得的估计OR为3.26（95%置信区间：2.12 - 5.02）。此外，胃癌亚组研究显示OR为3.74（95%置信区间：2.47 - 5.66），其他癌症类型报告的OR为2.92（95%置信区间：1.16 - 7.32）。
结论
本研究表明，STn肿瘤阴性患者的生存时间显著长于阳性患者。
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