Ma X C, Terata N, Kodama M, Jancic S, Hosokawa Y, Hattori T
First Department of Surgery, Shiga University of Medical Science, Otsu, Japan.
Eur J Cancer. 1993;29A(13):1820-3. doi: 10.1016/0959-8049(93)90529-o.
Expression of sialyl-Tn antigen (STN) was examined by an immunohistochemical method in 85 primary gastric carcinomas. The STN expression occurred in 53 (62.4%) cancers, and the positive staining was correlated with degree of gastric wall and lymph vessel invasion, lymph node metastasis, and stage of tumour. Five-year survival rates of patients with STN-positive cancers (47.2%) were significantly lower than those with STN-negative cancers (84.4%) (P < 0.01), and patients with STN-positive cancers at stage III and stage IV had a worse prognosis. In the cancers with serosal invasion, patients with STN-positive cancer disclosed a significantly poorer prognosis than those with STN-negative cancers (P < 0.01). Therefore, it is suggested that a careful follow-up study and intensive postoperative therapy are needed for patients with advanced gastric cancers with positive STN expression.
采用免疫组织化学方法检测了85例原发性胃癌中唾液酸化-Tn抗原（STN）的表达情况。53例（62.4%）癌症出现STN表达，且阳性染色与胃壁浸润程度、淋巴管浸润、淋巴结转移及肿瘤分期相关。STN阳性癌症患者的5年生存率（47.2%）显著低于STN阴性癌症患者（84.4%）（P<0.01），且Ⅲ期和Ⅳ期STN阳性癌症患者的预后更差。在有浆膜浸润的癌症中，STN阳性癌症患者的预后明显比STN阴性癌症患者差（P<0.01）。因此，建议对STN表达阳性的进展期胃癌患者进行仔细的随访研究和强化术后治疗。
