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高迁移率族蛋白A1（HMGA1）基因在各种结肠癌细胞系中的表达及其与预后的相关性。

High-mobility group A1 () gene expressions in various colorectal cancer cell lines and correlation with prognosis.

作者信息

E Maruthi Prasad, Liu Ting, Zhang Xiang, Yang Hongli, Wang Jing, Huang Renpeng, Wang Yuhong

机构信息

Department of Pathology, The First Affiliated Hospital of Soochow University, Suzhou 215000, China.

Department of Cell Biology and Genetics, Shenzhen Key of Laboratory of Translational Medicine of Tumor, Shenzhen University Health Science Center, Shenzhen 518060, China.

出版信息

Transl Cancer Res. 2020 Feb;9(2):763-773. doi: 10.21037/tcr.2019.12.10.

DOI:10.21037/tcr.2019.12.10
PMID:35117422
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8798761/
Abstract

BACKGROUND

The high-mobility group A1 gene (HMGA1) plays a major role in the development of malignant cancers. However, the mechanisms underlying the correlation between HMGA1 expression level and patients' overall survival rate in various malignant cancers is unclear.

METHODS

We used The Cancer Genome Atlas (TCGA) database (https://genome-cancer.ucsc.edu/) to search for mRNA expression levels of in tumor patients and grouped them by receiver operating characteristic (ROC) curve. This divided patients into a high expression cohort and low expression cohort, and Kaplan-Meier analysis revealed the overall survival of the cancer patients. We also used real-time quantitative PCR (qPCR) to detect the expression of , , , and gene was detected by normalized to the expression of β-actin in colorectal cancer cell lines.

RESULTS

High expression group correlated with worse survival prognosis statistically significant (P<0.05), and scatter plots showed high expression in the different cancers (lung cancers; lung adenocarcinoma and lung squamous cell carcinoma; stomach and colorectal cancers; liver and pancreatic cancer; kidney papillary cell carcinoma; kidney clear cell carcinoma, brain lower grade glioma; adrenocortical cancer; acute myeloid leukemia; and sarcoma; head and neck squamous cell carcinoma, cholangio and bladder urothelial cancers). Further, we also found that the mRNA expressions of , and - genes significantly in colorectal cancer cell lines (P value: 0.0005), consistent with the results of HMGA1 in TCGA database.

CONCLUSIONS

is highly expressed in various cancers than normal tissues, and high expression levels of HMGA1 correlated with a worse prognosis. The gene expressions and the TCGA data clearly supports that targeting in the management of cancers increases the survival rate of cancer patients.

摘要

背景

高迁移率族蛋白A1基因（HMGA1）在恶性肿瘤的发生发展中起主要作用。然而，HMGA1表达水平与各种恶性肿瘤患者总生存率之间相关性的潜在机制尚不清楚。

方法

我们使用癌症基因组图谱（TCGA）数据库（https://genome-cancer.ucsc.edu/）搜索肿瘤患者中HMGA1的mRNA表达水平，并通过受试者工作特征（ROC）曲线对其进行分组。这将患者分为高表达队列和低表达队列，Kaplan-Meier分析揭示了癌症患者的总生存率。我们还使用实时定量PCR（qPCR）检测结直肠癌细胞系中HMGA1、miR-143、miR-145和E-cadherin基因的表达，并将其标准化为β-肌动蛋白的表达。

结果

高表达组与较差的生存预后具有统计学意义（P<0.05），散点图显示HMGA1在不同癌症（肺癌；肺腺癌和肺鳞癌；胃癌和结直肠癌；肝癌和胰腺癌；肾乳头状细胞癌；肾透明细胞癌、脑低级别胶质瘤；肾上腺皮质癌；急性髓系白血病；和肉瘤；头颈部鳞状细胞癌、胆管癌和膀胱尿路上皮癌）中高表达。此外，我们还发现结直肠癌细胞系中miR-143、miR-145和E-cadherin基因的mRNA表达显著下调（P值：0.0005），与TCGA数据库中HMGA1的结果一致。

结论

HMGA1在各种癌症中比正常组织中高表达，且HMGA1的高表达水平与较差的预后相关。基因表达和TCGA数据清楚地支持在癌症治疗中靶向HMGA1可提高癌症患者的生存率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9091/8798761/0116ed9cbd78/tcr-09-02-763-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9091/8798761/0ac4bff052e7/tcr-09-02-763-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9091/8798761/48c4f4e95bd9/tcr-09-02-763-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9091/8798761/8fdeac1619f4/tcr-09-02-763-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9091/8798761/3163c4679543/tcr-09-02-763-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9091/8798761/7dbd0473459a/tcr-09-02-763-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9091/8798761/8157799967de/tcr-09-02-763-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9091/8798761/0116ed9cbd78/tcr-09-02-763-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9091/8798761/0ac4bff052e7/tcr-09-02-763-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9091/8798761/48c4f4e95bd9/tcr-09-02-763-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9091/8798761/8fdeac1619f4/tcr-09-02-763-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9091/8798761/3163c4679543/tcr-09-02-763-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9091/8798761/7dbd0473459a/tcr-09-02-763-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9091/8798761/8157799967de/tcr-09-02-763-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9091/8798761/0116ed9cbd78/tcr-09-02-763-f7.jpg

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