Wan Shaoxiang, Tang Qi, Feng Daying, Hu Zaoxiu, Shao Weiqing, Chen Yajuan
Kunming Medical University, Kunming 650500, China.
Second People's Hospital of Yunnan, The Fourth Affiliated Hospital of Kunming Medical University, Kunming 650031, China.
Transl Cancer Res. 2020 Apr;9(4):2692-2700. doi: 10.21037/tcr.2020.02.63.
Colorectal cancer (CRC) is one of the world's deadliest cancers, and its mortality rate has been on the rise in China. Yunnan is a region with a higher concentration of ethnic minorities. CRC affects many people from ethnic minority groups, which differ from Han in terms of their age and gender compositions.
We collected samples from 1,016 cases of CRC patients along with their case files at Yunnan Provincial Cancer Hospital from the period between January 2013 and December 2018.
In total, 7.1% (n=72) of all lung cancer cases diagnosed from 2013 to 2018 in Yunnan Provincial Cancer Hospital occurred in patients 40 years old or younger, 44% (n=447) were 40 to 60 years old, and 48.9% (n=497) were 60 years old or above. The composition ratio of CRC patients in the different age groups differed significantly and enhanced significantly with age, with a statistical significance of P<0.05. A total of 33.6% (n=38) of 113 minority patients and 16.8% (n=152) of 903 Han patients reported a history of smoking, and 23.0% (n=26) of 113 minority patients and 14.6% (n=132) of Han patients had a history of drinking. Long-term smoking and drinking are significantly associated with the incidence of CRC, and this was more significant among ethnic minorities (P<0.05).
The high incidence of CRC in Yunnan is strongly related to patients' lifestyles, and diet should be a core focus of efforts to prevent and treat CRC. Early screening and regular check for common tumor markers can also help to reduce the incidence of CRC and provide a basis for improvements in CRC treatment and prognosis in Yunnan.
结直肠癌（CRC）是全球最致命的癌症之一，在中国其死亡率呈上升趋势。云南是少数民族聚居较为集中的地区。结直肠癌影响着许多少数民族群体的人，这些群体在年龄和性别构成上与汉族有所不同。
我们收集了2013年1月至2018年12月期间云南省肿瘤医院1016例结直肠癌患者的样本及其病历档案。
在云南省肿瘤医院2013年至2018年诊断的所有肺癌病例中，总计7.1%（n = 72）发生在40岁及以下患者中，44%（n = 447）为40至60岁，48.9%（n = 497）为60岁及以上。不同年龄组结直肠癌患者的构成比差异显著，且随年龄显著增加，P<0.05，具有统计学意义。113名少数民族患者中有33.6%（n = 38）有吸烟史，903名汉族患者中有16.8%（n = 152）有吸烟史；113名少数民族患者中有23.0%（n = 26）有饮酒史，汉族患者中有14.6%（n = 132）有饮酒史。长期吸烟和饮酒与结直肠癌的发病率显著相关，在少数民族中更为显著（P<0.05）。
云南结直肠癌的高发病率与患者的生活方式密切相关，饮食应成为结直肠癌防治工作的核心重点。早期筛查和定期检测常见肿瘤标志物也有助于降低结直肠癌的发病率，并为改善云南结直肠癌的治疗和预后提供依据。
