Sun Jing, Zhang Xiao, Huang He, Zhang Yi, Wang Kai, Cui Shiyun
Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
The First School of Clinical Medicine, Nanjing Medical University, Nanjing 210029, China.
Transl Cancer Res. 2020 Apr;9(4):3018-3023. doi: 10.21037/tcr.2020.02.74.
Pancreatic cancer is associated with a very poor prognosis highlighted by the close association between the disease incidence and mortality. Pancreatic cancer commonly metastasizes to the liver, peripancreas, common bile duct, stomach, duodenum, and retroperitoneum. Conversely, rectal metastasis from pancreatic cancer is extremely rare. We report a rare case of a 75-year-old man with rectal metastasis from a primary pancreatic carcinoma resected 2 years prior. The patient underwent radiotherapy and chemotherapy, but the patient died of increased tumor load. Our understanding of pancreatic cancer has advanced dramatically in the past decade. Distant metastasis should be taken into account when a patient has a medical history of pancreatic adenocarcinoma, even when a rare metastasis site is involved. Histopathological characteristics and immunohistochemical tests are helpful for diagnosis.
胰腺癌的预后非常差,疾病发病率和死亡率之间的密切关联凸显了这一点。胰腺癌通常会转移至肝脏、胰腺周围、胆总管、胃、十二指肠和腹膜后。相反,胰腺癌转移至直肠极为罕见。我们报告了一例罕见病例,一名75岁男性,其直肠转移瘤源于2年前切除的原发性胰腺癌。该患者接受了放疗和化疗,但最终因肿瘤负荷增加而死亡。在过去十年中,我们对胰腺癌的认识有了显著进展。当患者有胰腺腺癌病史时,即使涉及罕见的转移部位,也应考虑远处转移的可能性。组织病理学特征和免疫组化检测有助于诊断。