Guo Yu, Zhou Shui-Hong, Cao Zai-Zai, Bao Yang-Yang, Shen Li-Fang, Yao Hong-Tian
Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Front Oncol. 2022 Jan 18;11:769310. doi: 10.3389/fonc.2021.769310. eCollection 2021.
Langerhans cell sarcoma (LCS) is an extremely rare, malignant neoplasm that originates from Langerhans cells (LCs). Fewer than 70 cases have been reported in the English-language literature. LCS typically involves multiple organs, including the skin, lymph nodes, lungs, bone, bone marrow, liver, spleen, and soft tissues. Several etiological factors for LCS have been proposed, including immunosuppression, virus infection, and prior hematological disease. We report a rare case of LCS with Epstein-Barr virus (EBV) infection; bilateral cervical giant cysts were the initial manifestation. To our knowledge, this is the first report of LCS with EBV infection. The case information was complete, and the relevant literature was reviewed to gain insight into LCS. The case raises new questions on the oncogenic character of EBV.
朗格汉斯细胞肉瘤（LCS）是一种极其罕见的起源于朗格汉斯细胞（LC）的恶性肿瘤。英文文献报道的病例少于70例。LCS通常累及多个器官，包括皮肤、淋巴结、肺、骨、骨髓、肝、脾和软组织。已提出LCS的几种病因，包括免疫抑制、病毒感染和既往血液系统疾病。我们报告1例罕见的伴有EB病毒（EBV）感染的LCS；双侧颈部巨大囊肿为首发表现。据我们所知，这是首例伴有EBV感染的LCS报告。病例信息完整，并复习相关文献以深入了解LCS。该病例对EBV的致癌特性提出了新问题。
