Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Ren-Ai Road 199, 215123 Suzhou, China.
Chem Commun (Camb). 2022 Feb 22;58(16):2734-2737. doi: 10.1039/d1cc06247f.
A practical nickel- and photoredox-catalyzed Csp-H monofluoroalkenylation through chelation-assisted Csp-F bond cleavage of -difluoroalkenes for the synthesis of stereodefined tetrasubstituted fluoroalkenes has been developed. Moreover, the -difluoroalkenes can also undergo photoredox-catalyzed cascade twofold C-F diaminomethylation.
通过螯合辅助的 -二氟烯 Csp-F 键断裂，实现了一种实用的镍和光氧化还原催化的 Csp-H 单氟烯基化反应，用于合成立体定义的四取代氟烯烃。此外，-二氟烯还可以经历光氧化还原催化的级联双 C-F 二氨甲基化反应。
