Wang Yanhui, Tsui Gavin Chit
Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR 999077, China.
Org Lett. 2023 Aug 25;25(33):6217-6221. doi: 10.1021/acs.orglett.3c02452. Epub 2023 Aug 16.
A highly diastereoselective Pd(0)-catalyzed Mizoroki-Heck reaction of -difluoroalkenes is described. Unlike previously reported C-F bond functionalization with organometallic reagents, this reaction takes place between two different alkenes to achieve a formal C-F and C-H bond cross-coupling via a distinct pathway. Monofluorinated 1,3-diene products can be synthesized with control of the geometry of each alkene and good functional group tolerability.
描述了一种高度非对映选择性的钯（0）催化的二氟烯烃的 Mizoroki-Heck 反应。与先前报道的用有机金属试剂进行的 C-F 键官能化不同，该反应发生在两种不同的烯烃之间，通过独特的途径实现形式上的 C-F 和 C-H 键交叉偶联。可以在控制每种烯烃几何构型的情况下合成单氟代 1,3-二烯产物，并且具有良好的官能团耐受性。
