Dermatology Unit, IRCCS Policlinico Sant'Orsola, Department of Experimental, Diagnostic and Specialty Medicine (DIMES) Alma Mater Studiorum University of Bologna, Bologna, Italy.
Private Dermatology Practice, Lugano and Bellinzona, Switzerland.
Clin Exp Dermatol. 2022 Jun;47(6):1165-1168. doi: 10.1111/ced.15110. Epub 2022 Feb 18.
Nail disorders in general are difficult to treat and often frustrating, and this is also the case with nail psoriasis, especially when it is limited to the nails, and not affecting joints. The quality of life of patients with nail psoriasis is negatively affected, owing to the chronic course of the disease and frequent relapses. The purpose of this study was to compare treatment response and maintenance of response during follow-up of 12 patients with nail matrix psoriasis limited to a few nails, who were treated with intralesional injections of either methotrexate (MTX) 25 mg/mL or triamcinolone acetonide 10 mg/mL. Patients were treated every 6 weeks for 24 weeks and followed up for 6 months. Photographic documentation and assessment by Nail Psoriasis Severity Index were performed during each treatment session and at each follow-up visit. At the end of the four treatment sessions, all patients had improvement of their disease, which continued during follow-up, especially for the MTX-treated group.
一般来说，指甲疾病很难治疗，而且往往令人沮丧，指甲银屑病也是如此，尤其是当它仅限于指甲，而不影响关节时。由于疾病的慢性过程和频繁复发，指甲银屑病患者的生活质量受到负面影响。本研究的目的是比较局限于少数指甲的甲母质银屑病患者的治疗反应和随访期间的反应维持情况，这些患者接受了甲内注射甲氨蝶呤（MTX）25mg/ml 或曲安奈德 10mg/ml。患者每 6 周治疗 24 周，并随访 6 个月。在每次治疗和每次随访时都进行了照片记录和指甲银屑病严重程度指数评估。在四轮治疗结束时，所有患者的疾病都有改善，而且在随访期间仍在继续，尤其是接受 MTX 治疗的患者。
