肿瘤微环境激活的基于纳米酶的试剂用于增强近红外二区的 MRI 引导光热治疗。
Tumor microenvironment activated nanoenzyme-based agents for enhanced MRI-guided photothermal therapy in the NIR-II window.
机构信息
State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China.
出版信息
Chem Commun (Camb). 2022 Feb 22;58(16):2742-2745. doi: 10.1039/d1cc07195e.
PMID:35119059
Abstract
We report a nanoenzyme-based photothermal agent, in which the nanoenzyme acts as a peroxidase, prodrug carrier, and MRI contrast agent. The formation of a dimer by the prodrug under the catalysis of the nanoenzyme in the tumor microenvironment causes photothermal conversion activation and MRI signal amplification simultaneously.
摘要
我们报道了一种基于纳米酶的光热试剂，其中纳米酶同时充当过氧化物酶、前药载体和 MRI 造影剂。在肿瘤微环境中，纳米酶催化前药形成二聚体，同时引起光热转换激活和 MRI 信号放大。
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