Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
J Dtsch Dermatol Ges. 2022 Feb;20(2):141-148. doi: 10.1111/ddg.14677. Epub 2022 Feb 4.
Calcinosis cutis is a heterotopic accumulation of calcium salts in the skin. It has been described as a late-onset complication of burn scars in a few cases, in contrast to heterotopic ossification, which may be an early-onset complication of burn injuries. Diagnosis of calcinosis can be confirmed by radiography, ultrasonography, computed tomography, magnetic resonance imaging or histology. Almost all cases of late-onset calcinosis in burn scars present as non-healing ulcers on the lower extremities near contracture bands. It has been hypothesized that this localization is due to the more frequent microtrauma of the lower extremities, and that ulceration is due to the presence of calcium deposits as foreign bodies. In our study, the mean age at the time of burn injury was 12.5 ± 8.27 years, and calcinosis developed after a mean time of 37.5 ± 14.95 years (mean age at onset was 50.5 ± 14.53 years). There was no significant difference between burn scars managed with skin grafting and those where skin grafting was not carried out. The ulcers healed after resection or extraction of the deposits without any recurrence at the same site. In contrast to previously reported cases, we observed two cases of non-ulcerating late-onset calcinosis in burn scars of the upper extremities.
皮肤钙化症是钙盐在皮肤中的异位积聚。有少数病例描述为烧伤瘢痕的迟发性并发症，而不同于异位骨化，后者可能是烧伤损伤的早期并发症。皮肤钙化症的诊断可以通过放射学、超声、计算机断层扫描、磁共振成像或组织学来确认。几乎所有烧伤瘢痕的迟发性钙化症病例均表现为挛缩带附近下肢的不愈合溃疡。据推测，这种定位是由于下肢更频繁的微创伤，溃疡是由于钙沉积物作为异物的存在。在我们的研究中，烧伤损伤时的平均年龄为 12.5 ± 8.27 岁，钙化症在平均 37.5 ± 14.95 年后发展（发病的平均年龄为 50.5 ± 14.53 岁）。接受植皮治疗的烧伤瘢痕与未进行植皮治疗的烧伤瘢痕之间没有显著差异。切除或提取沉积物后溃疡愈合，同一部位无复发。与之前报道的病例不同，我们观察到两例上肢烧伤瘢痕的非溃疡性迟发性钙化症。
