假尿嘧啶核苷化：转录共调控中一个新的剪接调节因子。
Pseudouridylation: A new player in co-transcriptional splicing regulation.
机构信息
Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Av. Professor Egas Moniz, 1649-028 Lisbon, Portugal.
Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Av. Professor Egas Moniz, 1649-028 Lisbon, Portugal.
出版信息
Mol Cell. 2022 Feb 3;82(3):495-496. doi: 10.1016/j.molcel.2022.01.010.
PMID:35120645
Abstract
Martinez et al. (2022) uncovered a novel function for the most abundant modified nucleoside in RNA. The study shows that uridines at splice sites and splicing regulatory motifs in the pre-mRNA may be converted to pseudouridine during transcription and impact splicing decisions.
摘要
马丁内斯等人（2022 年）揭示了 RNA 中含量最丰富的修饰核苷的一个新功能。该研究表明，前体 mRNA 剪接位点和剪接调控元件处的尿嘧啶核苷在转录过程中可能被转化为假尿嘧啶核苷，并影响剪接决策。
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