细胞遗传学与骨髓移植
Cytogenetics and bone marrow transplantation.
作者信息
Palka G, Di Bartolomeo P, Iacone A, Di Girolamo G, Betti S, Calabrese G, Natale D, Stuppia L, Rieve A K, Torlontano G
出版信息
Cancer Genet Cytogenet. 1986 Mar 15;21(2):147-57. doi: 10.1016/0165-4608(86)90040-3.
The authors report hematologic and cytogenetic data on 19 patients treated with allogeneic bone marrow transplantation (BMT) for severe hematologic disorders: 8 patients with chronic myelogenous leukemia, 6 with acute leukemia, 3 with severe aplastic anemia, 1 with refractory anemia, and 1 with beta-thalassemia major. Cytogenetic assays were performed on marrow cells before conditioning, 30 days after BMT, and at subsequent times. The authors discuss the role of cytogenetic studies in the evaluation of bone marrow engraftment, leukemic transformation of the graft, and disease relapse.
作者报告了19例因严重血液系统疾病接受异基因骨髓移植（BMT）患者的血液学和细胞遗传学数据：8例慢性粒细胞白血病患者、6例急性白血病患者、3例严重再生障碍性贫血患者、1例难治性贫血患者和1例重型β地中海贫血患者。在预处理前、BMT后30天及随后时间对骨髓细胞进行细胞遗传学检测。作者讨论了细胞遗传学研究在评估骨髓植入、移植物白血病转化和疾病复发中的作用。
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