Centre for Trans-disciplinary Research, Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute for Medical and Technical Sciences, Chennai, 600077, Tamil Nadu, India.
Centre for Trans-disciplinary Research, Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute for Medical and Technical Sciences, Chennai, 600077, Tamil Nadu, India.
Chem Biol Interact. 2022 Mar 1;355:109831. doi: 10.1016/j.cbi.2022.109831. Epub 2022 Feb 2.
Bone disorders have become a global concern illustrated with decreased bone mineral density and disruption in microarchitecture of natural bone tissue organization. Natural compounds that promote bone health by augmenting osteoblast functions and suppressing osteoclast functions has gained much attention and offer greater therapeutic value compared to conventional therapies. Amongst several plant-based molecules, flavonoids act as a major combatant in promoting bone health through their multi-faceted biological activities such as antioxidant, anti-inflammatory, and osteogenic properties. They protect bone loss by regulating the signalling cascades involved in osteoblast and osteoclast functions. Flavonoids augment osteoblastogenesis and inhibits osteoclastogenesis through their modulation of various signalling pathways. This review discusses the role of various flavonoids and their molecular mechanisms involved in maintaining bone health by regulating osteoblast and osteoclast functions.
骨骼疾病已成为全球关注的问题，表现为骨矿物质密度降低和天然骨组织微结构破坏。通过增强成骨细胞功能和抑制破骨细胞功能来促进骨骼健康的天然化合物已引起广泛关注，并提供了比传统疗法更高的治疗价值。在几种植物源性分子中，类黄酮通过其多种生物活性（如抗氧化、抗炎和成骨特性），作为促进骨骼健康的主要因子。它们通过调节涉及成骨细胞和破骨细胞功能的信号级联反应来保护骨质流失。类黄酮通过调节各种信号通路来促进成骨细胞生成和抑制破骨细胞生成。本综述讨论了各种类黄酮及其分子机制在通过调节成骨细胞和破骨细胞功能维持骨骼健康方面的作用。
