Ben-Neriah Y, Bernards A, Paskind M, Daley G Q, Baltimore D
Cell. 1986 Feb 28;44(4):577-86. doi: 10.1016/0092-8674(86)90267-9.
The cellular abl proto-oncogene encodes a protein-tyrosine kinase and is expressed in many cell types in two or three mRNA size species. Four types of mouse c-abl cDNAs have been cloned from 70Z/3 lymphoid cells that have different 5' sequences encoding predicted N-terminal regions of 20-45 amino acids. One of the four cDNAs has a predicted N-terminal sequence of met-gly-gln in common with the gag N terminus of v-abl. The 5' heterogeneity appears to be generated by alternative addition of 5' exons onto a common set of 3' exons. Alternative splicing occurs at the same site at which bcr sequences join to abl sequences in the Philadelphia chromosome translocation.
细胞原癌基因abl编码一种蛋白酪氨酸激酶，在多种细胞类型中以两三种mRNA大小的种类表达。已从70Z/3淋巴细胞中克隆出四种小鼠c-abl cDNA，它们具有不同的5'序列，编码预测的20 - 氨基酸的N端区域。这四种cDNA中的一种具有与v-abl的gag N端相同的预测N端序列met-gly-gln。5'异质性似乎是由5'外显子选择性地添加到一组共同的3'外显子上产生的。选择性剪接发生在费城染色体易位中bcr序列与abl序列连接的同一位置。
