Wen-Ting Li, Chang-Wei Wu, De-Jian Bian, Wei Sha
Department of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University, Shanghai, 200433, People's Republic of China.
Department of Emergency, Shanghai Pulmonary Hospital, Tongji University, Shanghai, 200433, People's Republic of China.
Int J Infect Dis. 2022 Apr;117:87-92. doi: 10.1016/j.ijid.2022.01.060. Epub 2022 Feb 1.
We aimed to study whether arterial blood gas parameters, inflammatory markers, and coagulation indicators correlate with pulmonary artery systolic pressure (PASP) values in patients with active pulmonary tuberculosis (PTB).
A total of 121 patients with PTB who had a measurement of PASP by Doppler echocardiography in the active phase of tuberculosis were included in this study. We carried out univariate and multivariate linear regression analyses to determine factors correlated with PASP values. We excluded patients with other diseases or conditions that might lead to increased PASP.
Univariate linear regression analysis revealed positive correlations of age, white blood cell count, neutrophils ratio, Log procalcitonin, erythrocyte sedimentation rate, Log C-reactive protein, fibrinogen, Log D-dimer with PASP and showed an inverse correlation of arterial partial pressure of oxygen (PaO) and arterial oxygen saturation (SaO) with PASP. Multiple linear regression analysis demonstrated that PaO and Log procalcitonin remained correlated with PASP values.
PaO and procalcitonin were strongly correlated with PASP values in patients with active PTB. The degree of hypoxia and severity of secondary respiratory bacterial infection may influence PASP value in active PTB.
我们旨在研究活动性肺结核（PTB）患者的动脉血气参数、炎症标志物和凝血指标是否与肺动脉收缩压（PASP）值相关。
本研究纳入了121例在肺结核活动期通过多普勒超声心动图测量PASP的PTB患者。我们进行了单因素和多因素线性回归分析，以确定与PASP值相关的因素。我们排除了患有其他可能导致PASP升高的疾病或状况的患者。
单因素线性回归分析显示，年龄、白细胞计数、中性粒细胞比例、降钙素原对数、红细胞沉降率、C反应蛋白对数、纤维蛋白原、D-二聚体对数与PASP呈正相关，动脉血氧分压（PaO）和动脉血氧饱和度（SaO）与PASP呈负相关。多因素线性回归分析表明，PaO和降钙素原对数仍与PASP值相关。
在活动性PTB患者中，PaO和降钙素原与PASP值密切相关。缺氧程度和继发性呼吸道细菌感染的严重程度可能会影响活动性PTB患者的PASP值。
