Mohan V, Snehalatha C, Ramachandran A, Viswanathan M
Diabetes Care. 1986 Jan-Feb;9(1):53-6. doi: 10.2337/diacare.9.1.53.
Serum C-peptide (CP) and immunoreactive insulin (IRI) responses were studied in 47 euglycemic offspring of patients with maturity-onset diabetes of the young (MODY). Mean IRI responses were not significantly different in nonobese offspring of MODY patients (O-MODY) but they were lower in obese O-MODY than in respective controls. Mean CP responses were low in both groups, the change being more pronounced in obese O-MODY. These findings indicate that alterations of secretion and metabolism of insulin can be detected even before glucose intolerance is seen in O-MODY.
对47例年轻的成年发病型糖尿病（MODY）患者的血糖正常的后代进行了血清C肽（CP）和免疫反应性胰岛素（IRI）反应的研究。MODY患者的非肥胖后代（O-MODY）的平均IRI反应无显著差异，但肥胖的O-MODY患者的IRI反应低于相应的对照组。两组的平均CP反应均较低，在肥胖的O-MODY患者中变化更为明显。这些发现表明，在O-MODY患者出现葡萄糖不耐受之前，甚至就能检测到胰岛素分泌和代谢的改变。
