Snehalatha C, Ramachandran A, Mohan V, Viswanathan M
Pancreas. 1986;1(2):139-42. doi: 10.1097/00006676-198603000-00005.
Pancreatic beta cell function in response to glucose was assessed in three different groups of offspring of conjugal diabetic parents (OCDP): those with normal glucose tolerance, those with impaired glucose tolerance (IGT), and those with diabetes. Serum immunoreactive insulin (IRI), C-peptide (CP), insulin/glucose (I/G) ratio, and IRI/CP ratios were estimated at fasting and 90 min after glucose load. Insulin secretion, measured as CP, was found to be low even in normal nonobese OCDP, but the change was not reflected in IRI value as the IRI/CP ratio was found to be elevated. The values decreased with increasing glucose intolerance. In obese OCDP, all the parameters were abnormal even among those with normal glucose tolerance, and further deterioration occurred with increasing glucose intolerance. The study shows that insulin secretory defects are detectable even in normal OCDP, and these changes deteriorate with increasing glucose intolerance. Differences are noted in the peripheral concentrations of IRI and CP between obese and nonobese OCDP before development of diabetes. After development of diabetes mellitus, these differences disappear, and the CP and IRI values in both groups are similar and low.
在三组双亲均患糖尿病的后代（OCDP）中评估了胰腺β细胞对葡萄糖的反应：葡萄糖耐量正常者、葡萄糖耐量受损（IGT）者和糖尿病患者。在空腹及葡萄糖负荷后90分钟时，测定血清免疫反应性胰岛素（IRI）、C肽（CP）、胰岛素/葡萄糖（I/G）比值以及IRI/CP比值。以CP衡量的胰岛素分泌，即使在糖耐量正常的非肥胖OCDP中也较低，但由于IRI/CP比值升高，这种变化并未在IRI值中体现出来。随着葡萄糖耐量受损程度加重，这些值降低。在肥胖的OCDP中，即使在葡萄糖耐量正常者中所有参数也都异常，并且随着葡萄糖耐量受损程度加重进一步恶化。该研究表明，即使在糖耐量正常的OCDP中也可检测到胰岛素分泌缺陷，并且这些变化随着葡萄糖耐量受损程度加重而恶化。在糖尿病发生之前，肥胖和非肥胖OCDP的外周IRI和CP浓度存在差异。糖尿病发生后，这些差异消失，两组的CP和IRI值相似且较低。
