Ioanna Pilati, UCL Division of Medicine, Faculty of Medical Sciences, University College London, London, UK,
J Frailty Aging. 2022;11(1):51-58. doi: 10.14283/jfa.2021.39.
Sarcopenic obesity (SO) is a condition combining two important public health issues commonly seen amongst older individuals, obesity and sarcopenia. Depressive symptoms are common among older people, whose population is increasing worldwide. Obesity and sarcopenia alone, are clearly associated with depression while the coexistence of these two conditions (SO) upon depressive disorders is currently unclear. We aimed to systematically review the association between primary SO and depressive disorders.
Searches were run on MEDLINE, EMBASE, PsycINFO, and CINAHL (inception to June 2019). One reviewer screened titles, abstracts, and full-texts, with 10% checked independently by a second reviewer. Cohort and cross-sectional studies were included. Two reviewers independently assessed risk of bias using the Mixed Methods Appraisal Tool. Results were narratively synthesised.
Out of the 7 studies eligible for inclusion, evidence of sarcopenic obesity as a predictor of depressive symptoms was found in two studies. The main observed trend was that diagnosing sarcopenia using muscle strength led to significant associations between sarcopenic obesity and depressive symptoms. Two cross-sectional studies found a significant association between SO and depressive symptoms, whilst three others found no statistically significant associations. All possessed some methodological limitations.
This is the first review to systematically examine a potential relationship between sarcopenic obesity and depressive disorders. Currently, the results are heterogeneous due to the large variability in assessment methods and outcome measurements. Future longitudinal studies would achieve greater confidence in the provisional conclusion that sarcopenic obesity, when measured using muscle strength, is associated with depressive symptoms.
肌少症性肥胖（SO）是一种将肥胖症和肌少症这两种常见于老年人的重要公共健康问题结合在一起的病症。抑郁症状在老年人中很常见，而全球老年人口正在增加。肥胖症和肌少症本身与抑郁症明显相关，而这两种情况（SO）共存与抑郁障碍的关系目前尚不清楚。我们旨在系统地综述原发性 SO 与抑郁障碍之间的关联。
我们在 MEDLINE、EMBASE、PsycINFO 和 CINAHL（从创建到 2019 年 6 月）上进行了检索。一名审查员筛选标题、摘要和全文，另一名审查员独立检查了 10%的内容。我们纳入了队列研究和横断面研究。两名审查员使用混合方法评估工具独立评估偏倚风险。结果以叙述性方式进行综合。
在符合纳入标准的 7 项研究中，有 2 项研究发现肌少症性肥胖是抑郁症状的预测因素。主要观察到的趋势是，使用肌肉力量诊断肌少症会导致肌少症性肥胖与抑郁症状之间存在显著关联。两项横断面研究发现 SO 与抑郁症状之间存在显著关联，而另外三项研究则未发现统计学上显著的关联。所有这些研究都存在一些方法学上的局限性。
这是第一项系统检查肌少症性肥胖与抑郁障碍之间潜在关系的综述。目前，由于评估方法和结果测量的巨大差异，结果存在异质性。未来的纵向研究将更有信心得出暂定结论，即使用肌肉力量测量的肌少症性肥胖与抑郁症状有关。
