Osamu Ezaki, M.D. Institute of Women's Health Science, Showa Women's University, 1-7-57 Taishido, Setagaya-ku, Tokyo 154-8533, Japan, Tel: +81-3-3411-7450; Fax: +81-3-3411-7450, E-mail:
J Frailty Aging. 2022;11(1):100-108. doi: 10.14283/jfa.2021.33.
Supplementation with 6 g/day of medium-chain triglycerides (MCTs) at dinnertime increases muscle function and cognition in frail elderly adults relative to supplementation with long-chain triglycerides. However, suitable timing of MCT supplementation during the day is unknown.
We enrolled 40 elderly nursing home residents (85.9 ± 7.7 years) in a 1.5-month randomized intervention trial. Participants were randomly allocated to two groups: one received 6 g/day of MCTs at breakfast (breakfast group) as a test group and the other at dinnertime (dinner group) as a positive control group.
Muscle mass, strength, function, and cognition were monitored at baseline and 1.5 months after initiation of intervention.
Thirty-seven participants completed the study and were included in the analysis. MCT supplementation in breakfast and dinner groups respectively increased right arm muscle area from baseline by 1.1 ± 0.8 cm2 (P<0.001) and 1.6 ± 2.5 cm2 (P<0.001), left arm muscle area by 1.1 ± 0.7 cm2 (P<0.001) and 0.9 ± 1.0 cm2 (P<0.01), right knee extension time by 39 ± 42 s (P<0.01) and 20 ± 32 s (P<0.05), leg open and close test time by 1.74 ± 2.00 n/10 s (P<0.01) and 1.67 ± 2.01 n/10 s (P<0.01), and Mini-Mental State Examination score by 1.5 ± 3.0 points (P=0.06) and 1.0 ± 2.1 points (P=0.06). These increases between two groups did not differ statistically significantly.
Supplementation with 6 g MCTs/day for 1.5 months, irrespective of ingestion at breakfast or dinnertime, could increase muscle mass and function, and cognition in frail elderly adults.
相较于长链甘油三酯，在晚餐时补充 6 克/天的中链甘油三酯（MCT）可增加虚弱老年人的肌肉功能和认知能力。然而，目前尚不清楚白天补充 MCT 的合适时间。
我们招募了 40 名年龄在 85.9 ± 7.7 岁的老年疗养院居民参加为期 1.5 个月的随机干预试验。参与者被随机分配到两组：一组在早餐时（早餐组）每天补充 6 克 MCT，作为实验组，另一组在晚餐时（晚餐组）补充，作为阳性对照组。
在干预开始前后的基线和 1.5 个月监测肌肉量、力量、功能和认知。
37 名参与者完成了研究并纳入分析。早餐和晚餐组分别使右臂肌肉面积从基线增加了 1.1 ± 0.8 cm2（P<0.001）和 1.6 ± 2.5 cm2（P<0.001），左臂肌肉面积增加了 1.1 ± 0.7 cm2（P<0.001）和 0.9 ± 1.0 cm2（P<0.01），右膝伸展时间减少了 39 ± 42 s（P<0.01）和 20 ± 32 s（P<0.05），腿开合测试时间减少了 1.74 ± 2.00 n/10 s（P<0.01）和 1.67 ± 2.01 n/10 s（P<0.01），简易精神状态检查评分增加了 1.5 ± 3.0 分（P=0.06）和 1.0 ± 2.1 分（P=0.06）。两组之间的这些增加没有统计学上的显著差异。
在 1.5 个月内每天补充 6 克 MCT，无论在早餐时还是晚餐时摄入，都可以增加虚弱老年人的肌肉量和功能以及认知能力。
